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Objectives: To compare LA function and strain by MRI in CA patients to a matched cohort of patients without cardiovascular disease, and to determine the connection with long-term clinical results in CA patients. Population data of a population with CA and 51 years-old, gender-, and race-matched controls without CVD who underwent MRI in sinus rhythm. For example, LA indexed minimum and maximum volumes, LA reservoir, contractile, and conduit strain were determined, as well as conduit strain. After adjusting for age, hypertension, the New York Heart Association's class, a new staging platform, and left ventricular ejection percentage for an endpoint of all-cause mortality and a composite endpoint of heart failure hospitalization or death, we compared groups. CA patients with median follow-up of 4. 9 months had significantly reduced LA strain and higher LA volumes in comparison to the matched cohort.
Source link: https://europepmc.org/article/MED/35801623
Background While cardiac transthyretin amyloidosis patients are quickly diagnosed with bone scintigraphy, the detection of cardiac light chain amyloidosis is difficult. Methods We had 35 patients with confirmed cardiac AL-amyloidosis and two control groups, as well as 70 patients with arterial hypertension who underwent CMR examination. The phenotype and degree of left ventricular hypertrophy, as well as the frequency and pattern of late gadolinium formation were investigated. Results Both the sensitivity and specificity of diffuse septal subcutaneous LGE in diagnosing cardiac AL-amyloidosis were 88% and 100%. In addition, a LV end-diastolic septal wall thickness of u2265 15 mm provided the most effective diagnostic results to distinguish cardiac AL-amyloidosis from HT. Conclusions The results from this report show that CMR could have the highest diagnostic success in the diagnosis of cardiac AL-amyloidosis.
Source link: https://europepmc.org/article/MED/35696411
LAS and LASR were assessed by MRI feature tracking in patients with biopsy-proven CA. Patients with CA's LAS and LASR were compared to healthy subjects and patients with hypertrophic cardiomyopathy. Patients with transthyretin and light chain amyloidosis were also investigated regarding differences between patients with transthyretin and light chain amyloidosis. In 22 CA patients, histological investigation revealed ATTR as CA subtype and AL in the remaining patients. Patients with CA and HCM were significantly reduced in patients with CA and HCM as compared to healthy controls, according to Reservoir LAS, conduit LAS, and booster LAS. In CA, Reservoir LAS and booster LAS were significantly reduced as compared to HCM patients. A linear correlation was established between LA' global reservoir strain and LA-EF, conduit strain, and global longitudinal LV strain, along with global booster strain and LA-EF, along with global longitudinal LV strain, global booster strain rate and LA-EF, and the Los Angeles area, which was at LVED.
Source link: https://europepmc.org/article/MED/35683537
Background To elucidate the role of texture analysis in detecting and distinguishing myocardial tissue alterations in patients with cardiac amyloidosis and hypertrophic cardiomyopathy. Methods In this retrospective review, 100 CA and 217 HCM patients who underwent CMR scans were included. Both the CA and HCM groups were randomly divided into a training dataset and a testing database. Following the introduction of the TA model in the training setting, the model's diagnostic results were confirmed in the testing procedure and further validated in a subgroup of patients with similar hypertrophy. By Delong's experiment, the significance of the difference between the AUCs of the TA model and late gadolinium enhancements was established. Conclusions Our analysis found that texture analysis based on T2-weighted images could be able to distinguish CA from HCM, even in patients with similar hypertrophy.
Source link: https://europepmc.org/article/MED/35597906
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