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The aim of this study was to determine the possibility of a radiomics-based late gadolinium enhancement cardiac magnetic resonance enhancement in the diagnosis of cardiac amyloidosis. Materials and Methods This retrospective analysis included 200 patients with biopsy-proven light-chain amyloidosis. Within our clinic's training cohort [mean age: 60 years, 42 men] and internal validation cohort [mean age: 56 years, 76 years, 71 men] were divided into training cohort [mean age: 97, mean age of 53 8 years, 72 men], with an average of 73%. Using the phase-sensitive reconstruction technique, Radiomics features were extracted from global left ventricular myocardium and three other segments on short-axis LGE images using the phase-sensitive reconstruction sequence. The two readers did qualitative and semi-quantitative analysis of the LGE images based on the visual LGE patterns, while quantitative analysis was done using a dedicated semi-automatic CMR system. Amyloidosis-related radiomics and the degree of myocardial involvement were tested. In all patients, moderate correlations between global or basal radiomics scores and Mayo stage were discovered. Conclusions A radiomics review of the LGE images provides incremental data when compared to the visual assessment and quantitative parameters on CMR to diagnose CA. Radiomics was moderately related to the severity of CA. Further studies are required to determine the prognostic significance of radiomics in patients with CA's patients.
Source link: https://doi.org/10.3389/fcvm.2022.818957
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