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Cardiac Amyloidosis Left Ventricular - Crossref

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Last Updated: 09 November 2022

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Global and regional left ventricular deformation evaluation with feature tracking in transthyretin cardiac amyloidosis. Comparison with echocardiographic findings

Abstract Background The diagnosis of cardiac amyloidosis is largely based on imaging methods. On speckle tracking TTE, a specific left ventricular deformation pattern with apical sparing has been described. With the latest tool feature monitoring cardiac magnetic resonance in California, there are no details about the LV global and regional analysis. Purpose Our aim is to determine the concordance of LV deformation between ST-TTE and FT-CMR. Methods Consecutive patients with definitive diagnosis of transthyretin CA, based on DPD scintigraphy, were retrospectively included, as well as imaging analysis with TTE and CMR. TTE-based projections from apical 2-, 3-, and 4-chambers were estimated on the same cine views of CMR using a specialized software of FT analysis, resulting in both global and segmental longitudinal strain values. The Student t-test was used to compare mean measurements obtained from both imaging technologies. 27 patients with a definitive diagnosis of TTR CA from our tertiary hospital were included, with 27 patients in a definitive diagnosis of TTR CA from our tertiary hospital. According to echocardiographic results, 80% of concentric LV hypertrophy with low median ejection fraction in the majority. When longitudinal LV strain parameters were compared, no differences were found in global and apical measurements, although basal and mid measurements were higher from CRM resulting in different apical indexes. In addition to 42 percent of the FT apical sparing, atypical u201ccherry on top-u201d pattern was found in ST analysis, but only 18% showed a typical u201d pattern. Conclusions Among patients with TTR CA, there were no differences between ST-TTE and FT-CMR in global longitudinal LV strain analysis.

Source link: https://doi.org/10.1093/eurheartj/ehac544.264


Echocardiographic assessment of left ventricular radial strain to differentiate cardiac amyloidosis from Fabry disease

Abstract Background : Left ventricular wall thickening is a common echocardiographic finding in infiltrative cardiomyopathies such as cardiac amyloidosis and Fabry disease. Specific layer LV strain patterns may be helpful in ruling out FD in patients with suspected infiltrative cardiomyopathy. Purpose in CA and FD The aim of this research was to investigate differences and the diagnostic value of layer-specific 2D STE-based radial LV strain indices. The diagnostic value of the respective LV strain values and the layer-specific strain gradient were used to distinguish FD and CA using A Receiver operating curve analysis. GSepi demonstrated a significant decline in patients with FD. u221216. 0 in FD; CA vs. u221217. 7 in FD; p 0. 001; GSendo u22120. 6 in FD; p 0. 001; and GSepi u22126. 1 in CA vs. u221217. 1 in FD; p 0. 001; p 0. 001; and p 0. 001 in vs. u221212131312121312131213121312131213131217121312131217121312171217121713131312131212131317121312171213121213131117121213133613131312161216121217131213171; a; u221212171312131312131712171313171213131317131. 31; vs. 661. 31; vs. 1; vs In CA vs. FD: u221219. 4 U00b14. 3 respectively; p 0. 001. GSendo had the highest diagnostic precision to discriminate CA and FD areas under the curve [CI] 0. 83, 92% [CI] 0. 73,0. 92 U20130. 92. Conclusions Based on a layer-specific strain analysis, strain values in CA patients were significantly reduced relative to FD's. The integration of layer-specific LV strain indices into the diagnostic process may help with patient care of patients with unclear thick heart pathology.

Source link: https://doi.org/10.1093/eurheartj/ehac544.064

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions