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Cardiac Amyloidosis - Springer Nature

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Last Updated: 05 September 2022

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Cardiovascular magnetic resonance for suspected cardiac amyloidosis: where are we now?

Cardiac amyloidosis is underdiagnosed condition of restrictive cardiomyopathy resulting in heart failure in a rapid rate. With superior tissue characterization, high-resolution imaging, and precise cardiac evaluation, CMR has emerged as a versatile tool in cardiac amyloidosis research, providing both qualitative and quantitative measurements.

Source link: https://doi.org/10.1007/s10741-022-10226-w


The utility of positron emission tomography in cardiac amyloidosis

In the quantification of disease prevalence and a serial follow-up of cardiac amyloidosis, conventional cardiac scintigraphy has demonstrated limited value. The introduction of specific amyloid-binding radiotracers in specialized positron emission tomography can potentially change currently used diagnostic procedures for the diagnosis of cardiac amyloidosis.

Source link: https://doi.org/10.1007/s10741-021-10183-w


Multi-parametric speckle tracking analyses to characterize cardiac amyloidosis: a comparative study of systolic left ventricular longitudinal myocardial mechanics

Cardiac amyloidosis, the most common cardiac storage disease, is associated with significant changes in left-ventricular morphology and function. We investigated seven parameters in patients with confirmed CAM to gain specific insight into LV systolic longitudinal myocardial mechanics. The findings were compared to those of people with healthy heart and another primary myocardial disorder with thickened myocardium and severe diastolic and systolic LV-dysfunction. Compared to healthy people, patients with CAM and LV-NC showed significant reduced LV-ejection-fraction, global longitudinal systolic peak-strain, strain-rate, and displacement. CAM patients with CAM demonstrated significantly reduced time-to-peak systolic longitudinal strain and time-to-peak strain-rate in comparison to healthy-hearts and the LV-NC group. Although the amount of the segmental strain and strain-rate in longitudinal mechanics varied between the groups, similar intraventricular baso-apical parameter-gradients were found for systolic longitudinal peak-strain and strain-rate, pre-systolic-index, post-systolic-index, and peak systolic displacement.

Source link: https://doi.org/10.1007/s00380-022-02047-6


The genetics of cardiac amyloidosis

Over 150 unique pathological point mutations within the transthyretin gene have been identified, with each exhibiting distinct clinical phenotypes and penetrance. The most common cause of hereditary ATTR in the United States is the Val122Ile point mutation, with a prevalence of 3. 4 percent in North Americans of African and Caribbean descent. The V30M mutation is the most common variant found among Caucasians with hereditary ATTR-CM. Overall, the prevalence of ATTR disease in the United States has been on the rise, perhaps due to an increase in practitioner awareness, the use of new non-invasive imaging techniques for ATTR diagnosis, and the development of multidisciplinary amyloid programs around the country. Notably, significant numbers of patients with signs of left ventricular thickening on cardiac imaging, senile stenosis, and/or signs of heart disease with preserved ejection fractions may have undiagnosed CA, particularly in the African American population.

Source link: https://doi.org/10.1007/s10741-021-10164-z


ST-elevation myocardial infarction among cardiac amyloidosis patients; a national readmission database study

Literature on recent trends and mortality of ST-elevation myocardial infarction in cardiac amyloidosis patients is limited. Hospitalizations related to STEMI in CA were analyzed for hospitalizations in the state of the United States. The national readmissions database sample, which accounts for more than 95% of the national sample, was analyzed for hospitalizations related to CA with STEMI. 439 had STEMI, out of a total of 4252 adult patients with diagnosis of CA, while 3813 had no STEMI. Compared to CA without STEMI, STEMI patients had higher rates of multi-organ manifestations including VT/VF, cardiogenic shock, AKI requiring dialysis, and ICU admissions than those in CA without STEMI. There were no correlations between CA patients and mortality among multivariate logistic regression studies. The overall yearly trends for prevalence and mortality among STEMI in CA patients remained stagnant over the study years. Coronary interventions may not have long-term health benefits.

Source link: https://doi.org/10.1007/s10741-021-10210-w


Tc-99m pyrophosphate scintigraphy for cardiac amyloidosis: concordance between planar and SPECT/CT imaging

The imaging procedure and the ideal cut-off points for quantitative assessment of technetium-99 million pyrophosphate cardiac amyloidosis scintigraphy remain controversial. The aim of this investigation was to determine the concordance between planar and SPECT images, as well as investigate the contribution of SPECT/CT to diagnostic precision. The study included all patients referred to our department for Tc-99m PYP cardiac imaging between April 2019 and April 2022. Planar and SPECT/CT images were achieved at a H/CL cut-off point of 1. 5 for 1-h photos and 1. 4 for 3-h images, with the highest degree of concordance between planar and SPECT/CT images. Planar imaging at both 1- and 3 h may be redundant, a lower H/CL cut-off point for 3-h planar images could lead to greater consistency in planar and SPECT imaging, and SPECT/CT in both 1- and 3 h may have significantly reduced equilateral results by offering significantly reduced equivocal results.

Source link: https://doi.org/10.1007/s10554-022-02676-y


Disease progression in cardiac morphology and function in heart failure: ATTR cardiac amyloidosis versus hypertensive left ventricular hypertrophy

Methods Fifty-one patients with ATTR-CA were compared with 20 patients with heart failure but no amyloidosis, but not with septal thickness >= 14 mm. Positive DPD diagnosis for ATTR-CA increased from 16 to 18, increased the interventricular septal thickness, and relative wall thickness in ATTR-CA, from 0. 51 to 0. 62 respectively, p 0. 45 and RELAPS > 2. 0. Conclusion The overtime rise in RWT and IVST in ATTR-CA patients was higher than that seen in patients with heart disease, but not cardiac amyloidosis.

Source link: https://doi.org/10.1007/s00380-022-02048-5


Comprehensive approach to cardiac amyloidosis care: considerations in starting an amyloidosis program

As knowledge of the disease increases, healthcare professionals within hospitals have collaborated to develop comprehensive amyloidosis services to better serve patients in the area. We discuss our findings in establishing a cardiac amyloidosis program at two hospitals that have recently started such programs in this research. The identification of multidisciplinary stakeholders, overarching program objectives, institutional buy-in, and a strong emphasis on program growth and development are all tenets of a successful program.

Source link: https://doi.org/10.1007/s10741-021-10163-0


Multimodality imaging approach to cardiac amyloidosis: part 2

In the extensive study of California, bone tracers were used to highlight the complementary role of traditional imaging techniques, such as electrocardiogram and echography, with advanced cardiac imaging, cardiac magnetic resonance, and nuclear cardiac scintigraphy. This book uses clinical experiences to illustrate the complementary role of traditional imaging techniques such as electrocardiogram and echography in conjunction with sophisticated cardiac imaging in tandem with advanced cardiac imaging with cardiac magnetic resonance and nuclear cardiac scintigraphy. We also emphasize the importance of light chain disease research as part of imaging research integration and discussion of the key aspects of various imaging techniques.

Source link: https://doi.org/10.1007/s10741-021-10179-6


Epidemiology and clinical manifestations of cardiac amyloidosis

With the availability of genetic testing and an increasing prevalence of certain mutations in African Americans, the hereditary aspects of ATTR have become more significant.

Source link: https://doi.org/10.1007/s10741-021-10162-1

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions