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Transthyretin amyloidosis is a slowly progressing disease characterized by abnormal deposits of amyloid in the body's organs and tissues. These protein deposits most often occur in the peripheral nervous system, which is made up of nerves connecting the brain and spinal cord to muscles, and sensory cells that sense sensations such as touch, pain, heat, and sound. Transthyretin amyloidosis comes in three main types, which are distinguished by their signs and organ systems that control. Transthyretin amyloidosis, the peripheral and autonomic nervous systems, play a role in peripheral neuropathy and difficulty controlling bodily functions. Some people suffer with heart and kidney disease as well as heart and kidney disease. Carpal tunnel syndrome is a condition of transthyretin amyloidosis that is characterized by numbness, tingling, and hand and finger weakness. Transthyretin amyloidosis, primarily affects the central nervous system. Amyloidosis occurs in the leptomeninges, which are two thin layers of tissue that cover the brain and spinal cord in people with this condition. When people with leptomening thyroid amyloidosis have eye problems, they are thought to be of the oculomeningeal variety. The heart is affected by transthyretin amyloidosis' cardiac manifestation. People with cardiac amyloidosis may have an abnormal heartbeat, an enlarged heart, or orthostatic hypertension. People with transthyretin amyloidosis can have mild peripheral neuropathy occasionally.
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