Cardiac Action Potential - Springer Nature

Long-term in vitro recording of cardiac action potentials on microelectrode arrays for chronic cardiotoxicity assessment

The proper identification of persistent cardiotoxic effects in vitro screenings is essential for filtering out harmful molecular substances ahead of in vivo animal experimentation and clinical trials. Here, we report that optoporation applied to microelectrode arrays allows detecting action potentials from human-derived cardiac syncytia for more than a month in a row and provides reliable data on chronic cardiotoxic effects caused by known drugs such as pentamidine.

Source link: https://doi.org/10.1007/s00204-022-03422-y

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