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We'll explore microRNAs that control human cardiac function growth and ask if their manipulation allows for therapeutic modulation of action potential abnormalities. According to action potential data in Long-QT syndrome myocytes, an extension of action potential in patient-specific induced pluripotent stem cell-derived cardiac myocytes extends action potential in myocytes isolated from a Short-QT syndrome patient by a definite increase in miR-365, specifically inhibiting miR-365 prolongs action time in myocytes isolated from a Short-QT syndrome myocytes dramatically prolongs action potential, while specific inhibition of miR-myocytes myocytes Eventually, refractory time measurements in human myocardial slices support the regulatory impact of miR-365 on adult human myocardial tissue. MiR-365 is used to limit human cardiac intervention potential duration by focusing on key causes of cardiac repolarization. Various forms of cardiac arrest may be related to an abnormal cardiac activity potential. Here the researchers demonstrate that microRNA-365 regulates cardiac action potential by modulating key cardiac repolarizing channels.
Source link: https://doi.org/10.1038/s41467-021-27856-7
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