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Cardiac Action Potential - Europe PMC

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Last Updated: 16 January 2022

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MicroRNA-365 regulates human cardiac action potential duration.

We'll discuss microRNAs that influence human cardiac function potential and ask if their manipulation allows for therapeutic modulation of action potential abnormalities. MiR-365 treatment prolongs action potential in myocytes derived from a Short-QT syndrome patient, according to specific inhibition of miR-365 results in pathologically prolonged action time in Long-QT syndrome myocytes. Lastly, refractory period measurements in human myocardial slices support the miR-365's regulatory effect on adult human myocardial tissue.

Source link: https://europepmc.org/article/MED/35017523


Inducing Ito,f and phase 1 repolarization of the cardiac action potential with a Kv4.3/KChIP2.1 bicistronic transgene.

The rapid transient outward potassium current plays a key role in phase 1 repolarization of the human cardiac action potential, and heart failure reduces the loss of contractility. In transfected HEK293 cells, Typical I to,f properties with slowed inactivation and accelerated recovery from inactivation due to the introduction of KChIP2. 1 with Kv4. 3 was observed. Both bicistronic components trafficked to the plasmamembrane and in adenovirus-induced rabbit cardiomyocytes, t-tubular and sarcolemmal construct labelling appeared, as well as adenovirus transduced rabbit cardiomyocytes. In rabbit cardiomyocytes, variation in the expression of the expressed I to,f reaffirmed typical species-dependent variations in AP morphology. Phase 1 to a non-failing human phenotype steered the rate of rise and magnitude of the Ca 2+ transient in a Simultaneous voltage recording and intracellular Ca 2+ imaging. The I to,f expression also reduced AP triangulation, but did not have an effect on I Ca,L, and I Na magnitudes.

Source link: https://europepmc.org/article/MED/34823101

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions