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MiR-365 elevation in patient-specific induced pluripotent stem cell-derived cardiac myocytes extends action potential in myocytes isolated from a Short-QT syndrome patient, according to the study, while specific inhibition of miR-365 in Long-QT syndrome myocytes leads to pathologically prolonged action potential in Long-QT syndrome myocytes. Lastly, human myocardial slices refractory time measurements show the miR-365's compliance on adult human myocardial tissue's action potential. Our findings show that miR-365 can be used to limit human cardiac arrest potential duration by focusing on key determinants of cardiac repolarization.
MMOs can be attributed to pathological early afterdepolarizations in heart cell behavior. The present paper intends to investigate a stochastic interpretation of the reduced Luo-Rudy model of cardiac action potential. We show that even in the parameter zone where the original deterministic system is characterized by canard-type limit cycles, poor additive noise can lead to MMOs. To conclude, this paper introduces and discusses new stochastic processes in the model of cardiac disease, and, moreover, the presented findings may be useful for studies of other complex models.
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