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Tumour-associated macrophages are assumed to add to oral squamous cell carcinoma initiation and progression. The phenotype of TAM recruitment in OSCC tissue samples was analyzed, subsequently identifying the influence of M2 macrophages and exosomes originated from M2 macrophages on OSCC proliferation and tumorigenesis \ n in vitro and in vivo. An exosomal RNA-seq analysis \ n was performed to predict regulatory exosomal miRNAs associated with OSCC growth, which established miR-31-5p and LATS2 for subsequent experiments. Mechanistically, miR-31-5p was supplied to recipient OSCC cells via M2 exos and complementary pairing with the huge tumor suppressor 2 \ n coding series, therefore suppressing the expression of LATS2 and inactivation the Hippo signaling path to sustain OSCC development. Collectively, our findings show that M2 macrophage-derived exosomal miR- 31-5p can make tumor suppressor LATS2 gene prevented and assist in the development \ n of OSCC using hindering the Hippo signaling pathway, which potentially offers new targets for the molecular therapy of OSCC.
Source link: https://doi.org/10.1166/jbn.2021.3066
Squamous cell carcinomas are therapeutically difficult tumor entities. Reduced response rates to radiotherapy and radiation treatment are generally observed in squamous patients and, accordingly, the death rate is fairly high contrasted to various other tumor entities. In squamous cell carcinoma, USP28 is highly expressed and stabilizes the essential squamous transcription element ΔNp63, with each other with important oncogenic aspects, such as C-JUN, c-myc and notch1. The hereditary alterations and cellular pathways that determine the function of USP28 in squamous cancer.
Source link: https://doi.org/10.3390/cells10102652
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