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Carcinoma pembrolizumab - Europe PMC

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Last Updated: 03 September 2022

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Real-world Therapeutic Outcomes of the Pembrolizumab Regimen as First-line Therapy for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Single-center Retrospective Cohort Study in Japan.

Object/aim This Japanese single-center retrospective cohort study sought to investigate peter and pepeb plus chemotherapy as the first-line therapy for patients with recurrent/metastatic head and neck cancer. Patients and methods Thirty-two Japanese patients with R/M SCCHN were analyzed between January 2020 and January 2022, based on the peterolizumab regimen. Conclusion The findings of the KEYNOTE-048 trial showed that pefolizumab's therapeutic efficacy and safety in real-world clinical practice were consistent with those of the KEYNOTE-048 study.

Source link: https://europepmc.org/article/MED/36039457


First-line pembrolizumab for patients with early relapsing urothelial carcinoma after perioperative chemotherapy: a retrospective analysis of bladder cancer and upper urinary tract cancer.

History and Origins Penetizumab is available for recurrent disease within 12 months after being given platinum-based perioperative chemotherapy. After the introduction of platinum-based perioperative chemotherapy, this review reviewed the oncological results of patients treated with pepolizumab compared to chemotherapy as the first-line therapy for early relapsing disease. Patients with early relapsing disease and fifteen patients with non-early relapsing disease were identified. Early relapsing disease was associated with shorter progression-free survival and overall health than non-early relapsing disease. Pesolizumab has been shown to have longer progression-free survival and disease prevention with disease control than chemotherapy in patients with early relapsing disease. In pegolizumab, there was no significant difference in overall survival between pembrolizumab and chemotherapy, but there was also a long tail. Conclusions peterizumab in early clinical settings for highly malignant tumors may be able to improve patients with early relapsing disease after the introduction of platinum-based perioperative chemotherapy.

Source link: https://europepmc.org/article/MED/36029377


Association of Neoadjuvant Pembrolizumab for Oral Cavity Squamous Cell Carcinoma With Adverse Events After Surgery in Treatment-Naive Patients.

The potential neoadjuvant role of programmed cell death 1 inhibitors in primary surgical care of HNSCC and its effects on surgical outcomes is uncertain. In a window-of-opportunity multi-institutional clinical trial evaluating neoadjuvant pembrolizumab for locally advanced HNSCC, asymptomatic patients with advanced oral cavity cancer receiving neoadjuvant pembrolizumab is evaluating neoadjuvant pembrolizumab is compared with matched controls. Participants and participants This retrospective cohort study at a single tertiary academic hospital included treatment-naive patients with locally advanced oral cavity squamous cell carcinoma (obstructive squamous cell carcinoma) who had under surgical resection. Exposures Patients with a local regionally developed resectable OCSCC who received neoadjuvant pembrolizumab were retrospectively analyzed for postoperative adverse events. Conclusions and relevance This cohort looked at surgical outcomes among patients with local regionally advanced OCSCC treated with neoadjuvant pegolizumab, finding that serious adverse events were similar to those in patients receiving standard-of-care therapy.

Source link: https://europepmc.org/article/MED/36006622


Improved survival in real-world patients with advanced urothelial carcinoma: A multicenter propensity score-matched cohort study comparing a period before the introduction of pembrolizumab (2003-2011) and a more recent period (2016-2020).

Objectives The treatment program for advanced urothelial carcinoma has drastically changed since pembrolizumab was introduced in 2017, but studies revealing current survival rates in aUC are lacking. This report was designed to determine the survival of real-world patients with aUC following the introduction of pembrolizumab and the direct survival-prolonging effect of pemerolizumab. PSM's latest era cohort had significantly longer CSS and OS than that of the previous era cohort. Patients treated with pepolizumab in secondary analyses using PSM had much longer CSS and OS than those in the previous era cohort, while patients who did not receive pemolizumab in the new era had similar outcomes as the earlier era cohorts. Patients with aUC treated in the recent period had a longer life span than those treated before the introduction of pedigolizumab.

Source link: https://europepmc.org/article/MED/35996761


EphrinB2 Inhibition and Pembrolizumab in Metastatic Urothelial Carcinoma.

Patients with metastatic urothelial carcinoma have poor prognosis after the failure of standard first-line chemotherapy failed. Low response rates are shown by the vaccination check point program, suggesting a significant unmet demand. Materials and methods In this phase II trial, patients with metastatic urothelial carcinoma that recurred or progressed after platinum-based chemotherapy received soluble EphB4-human serum albumin in combination with pemolizumab. The expression of sEphB4-HSA's goal EphrinB2 in the target was correlated with success. A objective response by twenty-six patients. The EphrinB2 was expressed by fifty-six patients, and among them, the median OS was 21. 5 months, with a complete response rate of 24%. The median PFS was 5. 7 months. Conclusions Based on historical results for programmed death ligand 1 monotherapy, the combination of sEphB4-HSA and petergist looks synergistic with improved OS and ORR.

Source link: https://europepmc.org/article/MED/35984996


The association between body mass index and efficacy of pembrolizumab as second-line therapy in patients with recurrent/metastatic head and neck squamous cell carcinoma.

BMI is a potential correlation between BMI and the success of immune checkpoint inhibitors in cancer patients, according to new studies. Pemolizumab is used to determine the prognostic value of the body mass index in recurrent/metastatic head and neck squamous cell carcinoma patients treated with pembrolizumab. Methods The current retrospective cohort study recruited 49 R/M HNSCC patients who underwent at least one cycle of pepolizumab as second-line therapy from June 2018 to October 2020. The BMI was significantly correlated with total survival time and progression-free survival time, according to the Kaplan-Meier study. Patients under the age of 60;ECOG; U22652; CPS 1 and rT4-stage all had a higher risk of mortality. Conclusions The BMI at the time of clinical diagnosis was discovered to be an independent predictive factor for R/M HNSCC patients receiving pembrolizumab. Patients with underweight patients have poorer clinical prognosis in comparison to normal weight patients.

Source link: https://europepmc.org/article/MED/35975731


Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results of the phase II PRIMMO study.

Patients with pre-treated persistent/recurrent/metastatic cervical or endometrial cancer are included in a phase II study. Pepolizumab was administered three-weekly from day 15 to day; one of the tumor lesions was radioactive on days 15, 17, and 19. At week 26, the primary endpoint was the objective response rate per immune-related response criteria. The irORR was 11. 1% in cervical cancer and 12. 0% in endometrial cancer, with 12. 9% in endometrial cancer. 4. 1 weeks in cervical cancer and 3. 6 weeks in endometrial cancer were both excluded from median overall survival of 39. 6 weeks and 37. 4 weeks, respectively. In ten cervical cancer patients and nine endometrial cancer patients, with Grade u2265 3 treatment-related adverse events were reported. When compared to nonresponders, responders had a significantly higher percentage of peripheral T cells.

Source link: https://europepmc.org/article/MED/35960332

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions