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Carcinoma invasion kinase - Crossref

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Last Updated: 03 November 2021

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Downregulation of Sulfiredoxin (Srx) Suppressed Cell Proliferation Migration and Invasion Through Inhibiting Extracellular Signal-Regulated Kinase/Nrf2 Pathway in Hepatocellular Carcinoma

The precise effects and underlying mechanism of Srx on the development of HCC are far from being totally understood. Materials and Methods: The abundances \ n of Srx in THLE-2 cell and HCC cell lines were established by western blot and RT-qPCR. The expression of MMP2, MMP9 and crucial participants in ERK/nuclear factor E2 relevant element signaling pathway was \ n spotted by performing western blot evaluation. Outcomes: We reported evidence that Srx was often up-regulated in HCC cell lines. Moreover, mechanistic investigations \ n indicated that Srx disturbance significantly hindered the activation of ERK/Nrf2 signaling pathway, and ERK activator TBHQ can reverse the functions of Srx interference in SK-Hep-1 cells. Final thought: Overall, Downregulation of Srx may impede HCC progression by subduing ERK/Nrf2 \ n indicating pathway. Searchings for in the current research study reported the functional participation and molecular mechanism of Srx in HCC, suggesting that Srx could have a possible healing value in HCC treatment.

Source link: https://doi.org/10.1166/jbt.2021.2784

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions