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Carcinoma invasion integrin - Europe PMC

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Last Updated: 03 November 2021

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Cancer-Associated Fibroblasts Promote Vascular Invasion of Hepatocellular Carcinoma via Downregulating Decorin-integrin β1 Signaling.

Vascular invasion of HCC consists of microvascular invasion and portal capillary growth thrombosis and is considered a typical roadmap of intrahepatic transition in HCC. However, the molecular mechanism underlying vascular invasion of HCC is largely unidentified. We discovered that extracellular matrix-related pathways were associated with vascular invasion of HCC which decorin secreted by cancer-associated fibroblasts was slowly downregulated from typical to tumor tissues and more so in PVTT cells. We additionally developed that low-level decorin expression is an independent danger aspect for MVI and it is related to a bad prognosis. Co-staining DCN and integrin β1 disclosed that DCN dynamically regulated integrin β1 protein expression. Co-IP assay confirmed the direct interaction of decorin with integrin β1. Our findings revealed that targeting cancer-associated fibroblast-related decorin is not only an appealing technique for hindering HCC vascular invasion and metastasis however additionally offers understanding into the medical treatment of patients with PVTT.

Source link: https://europepmc.org/article/MED/34504839

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions