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The role of positron-emission tomography in the evaluation of reaction to radiotherapy has been widely researched and accepted. In the research, four patients of carcinoma esophagus treated with neoadjuvant chemoradiotherapy followed by surgery were included. Mandard's method reported that the percentage change in pre and post-treatment maximum standardized uptake value of the primary tumor was related to histopathologic tumor regression classification according to the Mandard's formula. We could thus expect a good pathological reaction to chemoradiotherapy in our patient population, with a sensitivity of 95. 45% and a specificity of 72. 22%.
Source link: https://doi.org/10.4103/wjnm.WJNM_114_18
Whether [18F]-fluorodeoxyglucose-positron emission tomography scan could show the pathological response in esoph neoadjuvant concurrent chemoradiation and neoadjuvant concurrent chemotherapy. Thir patients of histopathologically confirmed, locally developed, potentially operable carcinoma esophagus including both squamous carcinoma and adenocarcinoma were randomly randomized into both NACCRT and NACT arms equally, and a randomised prospective study was carried out from March 2014 to October 2016. Patients with TRG 1u20132 were considered responders by TRG 1u20132, and 3u20135 were nonresponders. According to NACT group, the mean SUV in NACCRT group decreased from 15. 47 u00b1 2. 92 to 7. 31 %u00b1. 07; while in NACT group, mean SUV decreased from 15. 77 b1 3. 93 to 8. 68 u00b1 3. 89. Nevertheless, we found no statistically significant correlation between SUV% reduction and TRG. When compared to pathological response assessment, statistically significant decline in mean %u0394SUVmax and statistical significance correlation were found with statistical significance correlations.
Source link: https://doi.org/10.4103/wjnm.WJNM_23_17
Abstract Background The use of neoadjuvant therapy in resectable carcinoma esophagus has been elucidated. The search engine was redesigned to include just u201cneoadjuvantu201d, so that any bias in adjuvant care is eliminated. Only published randomized English language tests were accepted. The results were classified as neoadjuvant concurrent chemoradiation, neoadjuvant chemotherapy, neoadjuvant radiotherapy, and neoadjuvant sequential chemoradiotherapy based on neoadjuvant sequential chemoradiotherapy. Meta-analysis was done using the odds ratio and 95% CI on a fixed/random effects model. Heterogeneity was determined by chi-square and I2 tests. The Z probability variation among subgroups revealed a significant difference in Z probability. Results Twenty-five randomized trials involving 5272 patients were included in quantitative analysis for quantitative analysis. In 12 studies, NACRT was evaluated. However, 5-year OS was not found to be significantly superior. Surgery alone was not found to have any benefit over NACT, NART, and SCRT.
Source link: https://doi.org/10.1186/s12957-020-01830-x
Aims: The research is designed to determine if a correlation between apoptotic count and histological grading exists in squamous cell carcinoma of the esophagus, as well as reviewing the literature on such a relationship in the context of other tumors. Settings and Layout: Two cases of squamous cell carcinoma of the esophagus that appeared at a tertiary care center over a year were investigated. Materials and Methods: The endoscopic biopsy specimens of 56 patients of squamous cell carcinoma of esophagus were frozen in 10% buffered formalin, processed for routine paraffin sections, sections stained with hematoxylin and eosin, and examined under fluorescent microscope using a 40x objective and 10x microscope. Conclusions: An inverse correlation of the apoptotic count per HPF with the tumor's histological grade was discovered.
Source link: https://doi.org/10.4103/0974-2727.54801
We report on our experience with concurrent capecitabine-based chemoradiotherapy and intraluminal brachytherapy for middle-third esophageal cancer in this series. Methods and Techniques Twenty patients of histology-proven middle third esophageal cancer were treated with 45 Gray / 25 percent of external beam radiation on telecobalt were treated with five gray / 25 percent of telebolic cancer with a two-dimensional design with simultaneous cisplatin 40 mg/m2 twice daily for the first two weeks and last two weeks of radiotherapy, with five patients of histology-proven middle third esophage chemika chemo chemika cheme tology-proven middle et e hist chemo chem /25 fraction of e chem ray radiation on t e t het chemic t hehet t chem chemoty chemika chemadaxoe tuoe chemia sophageal adadot chemoesophageal cisplatin 40 mg/m2 chemoesophageal sophageal adod The actuarial longevity was 47% with five patients alive and two patients missing to follow-up at 3 years. At the end of seven years, two patients had their second primary tumor in the upper aerodigestive tract. Conclusion The treatment of carcinoma esophagus affected by the middle third of the esophagus is a safe and effective method.
Source link: https://doi.org/10.1055/s-0040-1708113
Esophageal carcinoma holds a special place in gastrointestinal carcinomas because it includes two main types, namely, squamous cell carcinoma and adenocarcinoma. While many modalities of dysphagia palliation are available, the patient's dysphagia surgical procedure must be chosen for the patient. This essay seeks to explore the recent trends in dysphagia palliation with promising findings and the most effective therapy for palliation of dysphagia in a given patient.
Source link: https://doi.org/10.4137/CGast.S30303
Squamous cell carcinoma and adenocarcinoma are two most common forms. Among the selected Bangladeshi patients with esophageal cancers, the present research sought to identify demographic, medical, histological characteristics, and links. The study's total 35 adult patients diagnosed with esophageal cancer were consecutively and positively included in the research. Results: Out of a total of 35 patients with esophageal cancer, 80% were more than 50 years old, while 71. 4% and 28. 6% were male and female respectively. Out of a total of 27 SCC, 15 had lesion in mid-esophagus, 9 in lower and three in upper esophagus. History of smoking and chewing betel nut were not significantly related to esophageal cancers. Conclusions: Esophageal carcinoma was common in elderly males, but SCC was more frequent than adenocarcinoma. The role of smoking and betel nut chewing in esophageal cancers in Bangladesh's population needs to be determined by a larger number of samples.
Background Esophageal cancers are more prevalent in East Asian countries, wherein squamous cell carcinomas are the most common histological subtype. There are very few published Indian studies relating to EC population trends. The present study was a retrospective review of the population of 917 patients hospitalized with ECs who were treated at our center for more than a 10-year period. Results and Discussion EC accounted for nearly 41% of the total cancer burden at our center from January 2002 to December 2011. Definitive chemoradiation was the most common mode of definitive control until; however, over the years, our most popular method of EC management has evolved to neoadjuvant chemoradiation, followed by surgery in the carefully chosen patients of locally selected resectable ECs. The incidence of esophageal ACs in the West has increased dramatically, but in our report, it was not seen in our study.
Source link: https://doi.org/10.1055/s-0041-1723103
People in Punjab's life style is different from those in India's other regions. Therefore, the risk factors contributing to esophageal carcinoma in Punjab may also be different than those in other parts of India. There are no previous studies into the risk factors for high incidence of esophageal carcinoma in this region. Methods: In Punjab, a case-control method will be used to determine potential risk factors associated with the development of carcinoma esophagus. After matching for gender, age, and place of residence, two controls for each esophageal cancer case will be selected. In water samples, heavy metals analysis will be carried out. Both oral and oral hygiene will be evaluated for mucosal growth as well as oral hygiene. Discussion: The findings of this report will help identify risk factors for high incidences of esophagus carcinoma in Punjab, ensuring that screening, prevention, and surveillance of esophagus carcinoma can be started right away.
Source link: https://doi.org/10.4103/jncd.jncd_33_19
Background: Carcinoma esophagus is a common malignant tumor in Pakistan, and it is the sixth most common tumor in the world. Methodology: It was a descriptive research carried out at DHQ Teaching Hospital D. I. Khan from August 2003 to March 2009. Following diagnosis and endoscopic findings, 89 histologically confirmed cases of esophageal carcinoma were collected. Results: Among 89 cases of esophageal carcinoma discovered in the United States, there were males and 24 females, with a male to female ratio of 2. 7:1. The overwhelming majority of patients 70 were from Zhob district, Afghanistan, and the tribal belt. The majority of the patients 66 were using tobacco in the form of chewing or smoking. Squamous cell carcinoma was more prevalent 75 years than adenocarcinoma 14. Conclusion: Esophageal carcinoma is more prevalent in males and vaping users. Middle third is the most common site affected, and squamous cell carcinoma is more common than adenocarcinoma.
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