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Carcinoma Prognosis - Europe PMC

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Last Updated: 03 January 2023

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Effect of blood product transfusion on the prognosis of patients undergoing hepatectomy for hepatocellular carcinoma: a propensity score matching analysis.

BACKGROUND Hepatectomy, the most common treatment for hepatocellular carcinoma, is accompanied by greater intraoperative blood loss than is resection of other malignancies. The effect of blood product transfusion on prognosis remains unclear. This report looked at the effects of blood product transfusion in patients with hepatocellular carcinoma hepatectomy. Methods We included 2015 patients with pathologically confirmed hepatocellular carcinoma who underwent hepatectomy at our hospital during 1990-2019. Conclusions Intraoperative blood loss was a good predictor of RBC transfusion fusion. All transfusion groups had lower rates of recurrence-free survival and overall survival than non-transfusion groups. The RBC group had a significantly lower 5 year OS rate than the no-RBC group and the FFP group than the no-FFP group. In patients with HCC patients who underwent radical liver transplantation of HCC, RBC transfusion increases hepatic cancer recurrence, and RBC/FFP transfusions reduced long-term survival and RFS and OS.

Source link: https://europepmc.org/article/MED/36592217


HSF1 expression in tumor-associated macrophages promotes tumor cell proliferation and indicates poor prognosis in esophageal squamous cell carcinoma.

Heat shock factor 1 is a potent, complicated carcinogen modulator, and esophageal cancer patients have a poor prognosis after HSF1 is high. Methods The TCGA website's HSF1 expression profile and patient survival results were analyzed, as well as patient survival data. By Sangerbox 3. 0, the infiltration of various types of immune cells in EC was determined based on HSF1 gene expression. HSF1 protein expression in 134 people with esophageal squamous cell carcinoma was determined by association with clinicopathological variables, and immunochemistry was used to measure HSF1 protein expression in 134 patients with esophageal squamous cell carcinoma. In an age-dependent manner, HSF1 was up-regulated in IL-4 stimulation THP1 cells. THP1-derived macrophages were more sensitive than tumor cells under heat stimulation conditions. The HSF1 knockdown in THP1 cell inhibited ESCC cells growth and proliferation in comparison to IL-4-induced-THP1 cells. The presence of HSF1 in TAMs can also indicate ESCC prognosis.

Source link: https://europepmc.org/article/MED/36586067


NLRP3 in tumor-associated macrophages predicts a poor prognosis and promotes tumor growth in head and neck squamous cell carcinoma.

In cancer, the NOD-like receptor family pyrin domain-containing 3 inflammasome plays cell- and tissue-specific roles, implying that its expression in various tumors or cells may play different roles in tumor formation. Although we've previously discussed the role of tumor-promoting NLRP3/IL-1b2 signaling in head and neck squamous cell carcinoma, the role in immune cells remains unclear. The number of NLRP3 high TAMs, however, was inversely linked to reduced overall survival in HNSCC patients. Thus, gene expression in TAMs may play a role in tumor formation and may have prognostic value in HNSCC.

Source link: https://europepmc.org/article/MED/36586012


High Hepcidin expression predicts poor prognosis in patients with clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (CR) is a common public health issue worldwide. Likewise, we found excellent diagnostic results of HAMP for ccRCC patients and its close ties with the clinicopathological characteristics of ccRCC patients. In addition, we discovered that HAMP is closely related to multiple immune pathways and positively associated with various immune cells in the same. In ccRCC patients, the expression of HAMP was associated with reduced clinical prognosis and increased immune cell infiltration. HAMP may have the ability to predict prognosis and clinical treatment success among ccRCC patients as a biomarker.

Source link: https://europepmc.org/article/MED/36585741


A comprehensive analysis of the FOX family for predicting kidney renal clear cell carcinoma prognosis and the oncogenic role of FOXG1.

Previous studies have shown that the forkhead box superfamily of transcription factors influences tumor formation and metastasis in multiple cancers. The aim of this research was to develop a model that depends on FOX family genes for predicting kidney renal clear cell carcinom prognosis, based on FOX family genes. From the Cancer Genome Atlas and International Cancer Genome Consortium datasets, we downloaded transcriptional profiles and clinical data of KIRC patients. We screened prognosis-related FOX family genes using Lasso regression and Multivariate Cox regression results to produce a new prognosis model. We used Lasso regression and Multivariate Cox regression analyses to develop a new prognosis model. In addition, we investigated whether prognosis-related FOX family genes are related to cellular immune responses in KIRC. Through an in vitro tumor function assay, we established the oncogenic role of FOXG1 in KIRC. In addition, a reduced level of immune cell infiltration and a lower immune response rate in patients with low risk scores, as well as those in patients with low risk scores, suggested a decreased risk of immune cell infiltration and a lower immune response rate in patients with low immune vulnerability.

Source link: https://europepmc.org/article/MED/36585925


Cancer Associated Macrophage-Like Cells in Metastatic Renal Cell Carcinoma Predicts for Poor Prognosis and Tracks Treatment Response in Real Time

The potential mRCC biomarker has been found in peripheral blood of patients with malignant tumors and has been shown to predict poor clinical patient outcomes based on their number and size. CAML changes were monitored during therapeutic regimens to see their ability to predict treatment success. Patients with smaller CAMLs had improved progression free survival and overall survival compared to patients with larger CAMLs, according to the study.

Source link: https://europepmc.org/article/PPR/PPR590292


C-Reactive Protein Levels After Esophagectomy are Associated with Increased Surgical Complications and Poor Prognosis in Esophageal Squamous Cell Carcinoma Patients.

However, the correlation between postoperative CRP levels and short- and long-term outcomes of esophageal squamous cell carcinoma patients following esophagectomy remains uncertain. Method We examined the records of 543 ESCC patients who underwent subcutaneous esophagectomy with gastric conduit reconstruction at Kumamoto University Hospital between August 2010 and July 2021. Mean CRP values were highest on day 3, and CRP levels after day 3 were correlated with grade > 2 complications based on the Clavien-Dindo classification. The optimal cut-off value for CRP day 3 levels was found to be 12. 19 mg/dL by receiver operating characteristic curve simulation, establishing the optimal cut-off value for CRP day 3 levels to be 12. 19 mg/dL. High CRP day 3 levels were highly correlated with grade > 2 difficulties, according to multivariate logistic regression studies. Conclusion Our results show that CRP day 3 levels can be used as a potential biomarker for predicting postoperative complications and that CRP day 7/8 levels may have potential prognostic value for ESCC patients following esophagectomy.

Source link: https://europepmc.org/article/MED/36581721


An Integrated Liver Function, Systemic Inflammation, and Tumor Characteristic Score Predicts Prognosis in Hepatocellular Carcinoma After Curative Resection.

The current research sought to create and validate a novel prognostic score that incorporates liver function, systemic inflammation, and tumor characteristics in a unified framework to forecast HCC's prognosis after curative resection. Patients with HCC who underwent curative liver transplantation were included in a training program. In two independent validation cohorts treated with either curative resection or transarterial chemoembolization, as well as 16 other models, predictive results and differentiation capability of the prognostic score were further investigated. With the highest C-index, likelihood ratio chi-square values, and Wald test results as well as the lowest Akaike information criterion, the FIBA scored showed an outperformed predictive value in both training and validation cohorts, outperform predictive value, as well as the lowest Akaike information criterion. Conclusion The FIBA score can be used to stratify HCC patients treated with curative resection.

Source link: https://europepmc.org/article/MED/36581722


Clinical value of serum AFP and PIVKA-II for diagnosis, treatment and prognosis of hepatocellular carcinoma.

In 145 cases of HCC, 57 cases of benign liver disease, 55 of cholangiocarcinoma and gallbladder carcinoma, 55 of other gastrointestinal tumors with liver metastasis, 56 of cholangiocarcinoma and gallbladder carcinoma, 55 of other gastrointestinal tumors with liver metastasis, 51 of other gastrointestinal tumors with liver metastasis, 5 of liver metastasis, 56 of benign liver disease, 55 of graft a and PIV patients of benign liver disease, cholan het gli cholan cholangiocarcinoma and gallbladder cancer, 55 of cholangiocarcinoma, 55 of ety, 55 of cholangiocarcinoma and gallbladder carcinoma, 55 of liver disease, 55 of liver metastasis, 55 of liver metastasis, 55 of liver cancer, 55 of cholangiocarcinoma and gallbladder carcinoma, 55 of liver disease, 55 of The changes in serum AFP and PIVKA-II levels before and after treatment in 47 HCC patients who underwent surgery and 77 who underwent interventional therapy were used to determine treatment success and prognosis in HCC. HCC group AFP and PIVKA-III's concentrations were considerably higher than those in other groups. After liver cancer surgery, the AFP and PIVKA-III indicators were significantly lower than those before surgery. Patients who were optimistic about PIVKA-II before surgery predicted disease progression, but those who were positive after surgery had worse prognosis than those who were negative.

Source link: https://europepmc.org/article/MED/36579611


High LRRC1 expression indicates poor prognosis of hepatocellular carcinoma

This study was designed to clarify the prognostic value of the leucine rich repeat containing 1 gene in hepatocellular carcinoma, as well as the determination of high and low LRRC1 expression on mutation and immune cell infiltration. LRRC1 was determined in HCC tumor and normal samples and was compared to normal and normal samples. Tumor samples were divided according to both high and low LRRC1 expressions. Genes associated with immune cells were discovered using weighted gene co-expression network analysis, and transcription factors of these genes were predicted. LRRC1 gene expression in HCC tissues had been upregulated, leading to a poor prognosis for patients with HCC. We found 15 differentially infiltrated immune cells in tumors with high and low LRRC1 expression, and 14 of them were correlated with LRRC1 gene expression, according to our analysis.

Source link: https://europepmc.org/article/PPR/PPR589610

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions