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We investigated the genetic enhancer landscape of Hepatitical Carcinoma using H3K27ac ChIP-seq and HiChIP samples from resected tumour samples of 30 patients, whose genome, transcriptome, and clinical trajectory data were available. Using previously published single cell RNA-seq results, we investigated the stochastic expression pattern of the overlapping genes in which the patients partially overlapped in some of the gain-in-tumour enhancer associated genes were fetal liver hepatoblast genes. The proportion of cells expressing epigenetic oncofetal genes clustered liver tissue samples into two groups - nearest normal liver-like or oncofetal-like.
Source link: https://www.ncbi.nlm.nih.gov/bioproject/875090
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