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Carcinoma Invasion - U.S. Department of Veterans Affairs

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Last Updated: 03 May 2022

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A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.

However, its role in clear cell renal cell carcinoma has not been discussed previously. During hypoxia in glioma cells, HIF-2 Up-regulates SK1 expression during hypoxia. Thus, we speculated that the stabilized HIF in ccRCC cells would be correlated with increased SK1 expression. We report that SK1 is overexpressed in 786-0 renal carcinoma cells devoid of functional VHL, as well as concomitant high S1P levels that appear to be HIF-2 mediated. In addition, looking at the TCGA's RNA seq database shows that SK1 expression was 2. 7-fold higher in solid tumor tissue from ccRCC patients, and that was associated with less survival. Cell proliferation had no effect on cell proliferation in 786-0 ccRCC cells. Also, S1P receptor 2 stimulation of FAK and invasion in phosphorylation of FAK and invasion.

Source link: https://doi.org/10.1096/fj.15-270413

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions