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Carcinoma Invasion - DOAJ

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Last Updated: 03 October 2022

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Cancer-Associated Stromal Cells Promote the Contribution of MMP2-Positive Bone Marrow-Derived Cells to Oral Squamous Cell Carcinoma Invasion

However, the role of stromal cells in the development of bone marrow-derived cells in oral squamous cell carcinoma invasion is uncertain. We isolated stromal cells from two OSCC patients: less invasive verrucous OSCC and highly invasive conventional OSCC, as well as highly invasive conventional OSCC and co-xenografted mice with the OSCC cell line on green fluorescent protein-positive bone marrow cells transplanted mice. By double fluorescent IHC, we traced the GFP-positive BM cells by immunohistochemistry and discovered matrix metalloproteinase 2 expression on BM cells.

Source link: https://doi.org/10.3390/cancers14010137

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions