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Carcinoma In Situ - DOAJ

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Last Updated: 10 September 2022

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Does concomitant ductal carcinoma in situ affect the clinical outcome in breast cancer patients with invasive ductal carcinoma: An Asian perspective

Abstract Background Ductal carcinoma in situ is an established precursor to invasive ductal carcinoma, and its coexistence with IDC appears to favour reduced biological vigour. This review included breast cancer patients with histological confirmation IDC, diagnosed and treated in a joint hospital from June 1, 2004 to June 30, 2014. Result and Analysis Methods and Results A total of 818 patients were identified, including 224 and 594 patients with isolated IDC and IDC with coexisting DCIS respectively. Patients with No. 2010DCIS were 1. 6 times more likely to experience disease progression and then associated with distant recurrences than those with no u2010DCIS. The five-year overall survival rate for patients with No-u2010DCIS and those with IDC-u2010DCIS was 90. 9% and 93. 7%, respectively. Conclusion The presence of DCIS in IDC among Asians is also linked to a favorable tumor biological profile, thereby indicating reduced disease aggressiveness.

Source link: https://doi.org/10.1002/cnr2.1646


Hypofractionation and Concomitant Boost in Ductal Carcinoma In Situ (DCIS): Analysis of a Prospective Case Series with Long-Term Follow-Up

We previously reported on a cohort of breast cancer patients with ductal carcinoma in situ who were treated with breast conservative surgery and hypofractionated whole-breast radiotherapy, providing a concomitant boost to the lumpectomy cavity. For this study, eighty-two patients with long-term monitoring were considered. Both univariate and multivariate models were used to determine the effect of pre-defined clinical findings on the risk of local recurrence. According to the LR surveys, the LR rates in 5 years and ten years were 2. 4% and 8. 2%, respectively. The univariate regression study, ER positive status, PgR positive status, and aggregate data of positive hormonal status were inversely correlated to LR risk, and LR risk. Positive hormonal stability has been shown to be protective against LR risk, according to our experience. A high tumor grad is a risk factor for LR.

Source link: https://doi.org/10.3390/life12060889


Metaplastic Matrix-Producing Carcinoma and Apocrine Lobular Carcinoma In Situ Associated with Microglandular Adenosis: A Unique Case Report

In about 30% of cases, there is a gradual transition to atypical microglandular adenosis, tumor in situ, and invasive breast carcinoma of several histologic subtypes, including an invasive carcinoma of no particular kind, metaplastic matrix-producing carcinoma, spindle cell carcinoma, spindle cell carcinoma, and adenoid cystic carcinoma. In this paper, we discuss a rare case of microglandular adenosis associated with metaplastic matrix-producing carcinoma and HER-2 neu oncoprotein-positive lobular carcinoma in situ with apocrine differentiation in a 79-year-old patient.

Source link: https://doi.org/10.3390/diagnostics12061458


Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients

Background: This research sought to evaluate and identify the specific CT findings in patients with small pancreatic cancer, as well as carcinoma in situ. Patients who were positive for each finding were compared between small PC and benign MPD stenosis groups. The proportion of patients with partial pancreatic atrophy related to the appearance of MPD stenosis increased in the small PC group than in the benign MPD stenosis group.

Source link: https://doi.org/10.3390/diagnostics10070445


A Potential Application of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Combined with Photodynamic Diagnosis for the Detection of Bladder Carcinoma in Situ: Toward the Future ‘MRI-PDD Fusion TURBT’

The detection of carcinoma in situ is vital in the treatment of high-risk non-muscle invasive bladder cancers in the United States. A total of 45 patients undergoing pre-surgical DCE-MRI and PDD-assisted endoscopic surgery were examined, as well as biopsies of the eight segments. For detecting CIS, we tested two different combinations of PDD and DCE-MRI. When either the PDD or DCE-MRI were test-positive, Combination 1 was positive. Both PDD and DCE-MRI were positive, but only when both PDD and DCE-MRI were test-positive.

Source link: https://doi.org/10.3390/diagnostics9030112


An insight into the invasion of breast ductal carcinoma in situ based on clinical, pathological and hematological data

Due to the significantly elevated prevalence of breast cancer, ductal carcinoma in situ has become a non-negligible component of breast cancers. Methods of Diagnosis The medical records of 389 patients with DCIS or DCIS with invasive ductal carcinoma were reviewed. According to pathology, the 324 patients in the training cohort were divided into invasion and non-invasion groups based on pathology. When invasive, tumor heterogeneity during migration was compared to study changes in the tumor heterogeneity during invasion. Patients in invasion and non-invasion groups were mixed in baseline characteristics, and no statistically significant differences were found for DCIS immunohistochemical markers. The IDC's Ki-67 percent of the IDC's peak was significantly higher than that of closely matched DCIS p 0. 001. Compared to the in-situ ones, Invasion tumor cells have a larger proliferative capacity. DCIS and matched IDC have linear correlations in HER2 expression and histological classifications. Different histological grades of DCIS subclones with different histological status will develop into invasive carcinomas in distinct invasive carcinomas.

Source link: https://doi.org/10.7717/peerj.13966


Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings

Background: Pancreatic cancer's rise is expected to increase at unprecedented rate; however, it's also unknown if the early stages of PC have a rapid growth rate comparable to advanced PCs. Methods: We reviewed the records of nine patients, including three patients with carcinoma in situ who had undergone magnetic resonance cholangiopancreatography to find solitary main pancreatic duct stenosis > 1 year before definitive PC diagnosis. We retrospectively investigated the time to diagnosis and first-time tumor detection from the estimated time point of first-time MPD stenosis detection without tumor lesion.

Source link: https://doi.org/10.3390/diagnostics11101858


Tumor Infiltrating Lymphocytes in Multi-National Cohorts of Ductal Carcinoma In Situ (DCIS) of Breast

In invasive breast cancer, Tumor-infiltrating lymphocytes are prognostic. However, their prognostic role in ductal carcinoma in situ has been disputed, despite this. In multi-national cohorts of Asian and European women, we used different scoring methods for TILs to explore the prognostic significance of TILs in the DCIS decision. In TILs evaluation guidelines in DCIS, the spatial arrangement of TILs may be a more helpful prognostic indicator in DCIS cases than stromal TILs alone, and can be included in TILs evaluation guidelines.

Source link: https://doi.org/10.3390/cancers14163916


A Rare Breast Tumor Confused with Ductal Carcinoma in Situ, Primary Solid Neuroendocrine Carcinoma

Sapino et al. first described the concept of pure neuroendocrine breast tumors. More than half of tumor cells must have neuroendocrine differentiation in order to diagnose neuroendocrine tumors. In this article, a patient with primary solid neuroendocrine breast cancer who had been diagnosed with ductal carcinoma in situ at another center was described, as well as morphological and immunohistochemical characteristics.

Source link: https://doi.org/10.5152/tjbh.2014.1725

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions