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RT versus full breast RT+ tumour bed lift is a time to local recurrence in women with DCIS treated with breast conserving surgery, followed by: full breast RT plus tumor bed increase, rather than the shorter one. To determine time to disease recurrence and overall survival in women with DCIS treated with breast conserving surgery and then divided breast RT plus tumour bed increase, RT using the standard fractionation schedule versus the shorter one. Breast RT+ tumour bed boost versus whole breast RT+ tumour bed enhancement; RT using the standard fractionation schedule versus the shorter version to compare the cosmetic effects. To determine the quality of life of women treated with: whole breast RT+ tumour bed boost; RT using the common fractionation scheme versus the shorter version.
Source link: https://clinicaltrials.gov/ct2/show/NCT00470236
In situ, the investigators will compare the use of two different creams for the treatment of low-risk skin cancers-superficial basal cell carcinoma and squamous cell carcinoma. 5-Fluorouracil cream is now FDA-approved for the treatment of superficial basal cell carcinoma in dermatologists around the world and in the Boston Medical Center for SCCis. Both skin cancers respond to the common treatment regimen, which is 4-weeks of the 5-fluorouracil cream. This combination cream has been shown to eliminate pre-skin cancers, actinic keratoses, and prevent future skin cancers from developing. The 2 forms of skin cancer are resistant to this shorter treatment regimen, so try this combination cream for 7-14 days to see if this shorter treatment course gives you cancer-free skin cancer. This combination cream is also used in this way to treat other subtypes of similar skin cancers.
Source link: https://clinicaltrials.gov/ct2/show/NCT05381597
Oral tamoxifen has reduced breast cancer risk by 50% in generally defined high risk women, with a 75% decrease in women at high risk due to atypical hyperplasia. The aim of the study is to determine short-term changes in background breast tissue in women with AH or LCIS who have either low-dose oral tamoxifen or topical 4-OHT gel.
Source link: https://clinicaltrials.gov/ct2/show/NCT04570956
A prospective cohort study, carried out in Canada, to determine whether the combination of clinicopathological results and the Oncotype DX DCIS score can identify a group of women at a risk of local recurrence after breast conserving surgery that do not require breast radiation therapy. We intend to screen 809 consenting women whose tumor tissue samples will be sent to Exact Sciences to determine their DCIS score. These patients will be enrolled and followed as part of the study, we expect that 526 women will have an Oncotype DX DCIS score 39 and a 10-year chance of local recurrence 10 years and a 10-year risk of local recurrence 10 percent. All patients with DCIS who require radiation oncology will be documented at each center. The DCIS score will be sent to the referring physician, according to the referring physician. The DCIS score findings will also be published on OCOG.
Source link: https://clinicaltrials.gov/ct2/show/NCT04797299
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