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Carcinoma - U.S. Department of Veterans Affairs

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Last Updated: 04 December 2022

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Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma.

As the Sod1KO mice begin showing signs of aging, they were given the senolytics, dasatinib, and quercetin at 6 months of age. The expression of p16 in Sod1KO mice's livers has been reduced to WT values and the expression of several senescence-associated secretory phenotype factors, which are both reduced. The Sod1KO mice had no effect on various indicators of liver fibrosis, but they did reduce the incidence of hepatocellular carcinoma by a drastic decrease in the incidence of hepatocellular carcinoma. D+ Q mice's necroptosis markers in the Sod1KO mice were also reduced to WT values, surprisingly. We also discovered that necroptosis in Sod1KO mice with necrostatin-1s reduced the markers of cellular senescence.

Source link: https://doi.org/10.1111/acel.13676


Revisiting laminin and extracellular matrix remodeling in metastatic squamous cell carcinoma: What have we learned after more than four decades of research?

Patients with squamous cell carcinoma have a dramatic decline in survival after the formation of distant metastases. SCCs have a definite yet flexible effect on their metastatic capacity. The extracellular matrix is a recurring yet dynamic influence on their metastatic capacity. However, studies in ECM alterations in several cancers have been broadly applied to all metastatic diseases, despite the fact that tumor characteristics vary by tumor type. We will only discuss how laminins influence the SCC metastatic process. Enhanced laminin protein deposition occurs at the invasive edge of SCC tumors, which correlates with elevated laminin-binding integrins, increased MMP-3 presence, worse prognosis, and lymphatic dissemination. Although these results are significant, there are still no reports on the emergence of a premetastatic niche, intra- and extravasation processes, and the contribution of the ECM to SCC metastatic cell dormancy. Such clinical interventions may dramatically improve quality of life and patient survival by specifically targeting SCC metastasis.

Source link: https://doi.org/10.1002/mc.23417

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions