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Carcinoma - BioRxiv

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Last Updated: 04 May 2022

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Risk modelling of single cell populations revealed the heterogeneity of immune infiltration in hepatocellular carcinoma

Hepatocellular carcinoma is one of the most common primary hepatic malignancies. The RB/E2F transcription factors play a significant role in the proliferation and progression of HCC, mainly via the RB/E2F pathway. We developed and validated a predictive model based on E2F expression, effectively stratifying HCC patients into two groups with different survival risks in this research. Then we tested the discriminating capability of the predictive model on infiltrating T cells, finding remarkable cell heterogeneity as well as changed cell fates. Moreover, single-sample gene set enrichment analysis showed that subsets of CD8+ T cells with significantly different cell adhesion characteristics could be linked to different types of tumor cell propagation. Therefore, our results linked the common prognostic gene signature to the immune microenvironment and cellular heterogeneity at the single-cell level, providing further insight into HCC tumorigenesis.

Source link: https://doi.org/10.1101/2021.06.26.450025

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions