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Oral squamous cell carcinoma is often diagnosed late, resulting in poor patient outcomes. Small RNA sequencing analysis along with data from The Cancer Genome Atlas revealed 12 differentially expressed miRNAs in OSCC patients as compared to controls. This 3-miRNA signature demonstrated higher efficacy of salivary exosomes in early detection and clinically linked to disease progression and overall survival of OSCC patients. By reversing the EMT process in an OECM-1 cell line, transfection-mediated upregulation of the 3-miRNA signature significantly reduced cell proliferation, induced apoptosis, resulting in cell cycle arrest in G2/M phase cell cycle arrest and reduced the invasive and migration risk. This research also reveals a 3-miRNA signature that can be used as a precursor for early detection of OSCC and uncovers the underlying mechanisms that cause converting a normal epithelial cell into a malignant phenotype.
Source link: https://doi.org/10.1101/2022.05.31.494114
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