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Carcinoma - Astrophysics Data System

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Last Updated: 04 September 2022

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Synergistic anti-tumor therapy by a homotypic cell membrane-cloaked biomimetic nanocarrier with exceptionally potent activity against hepatic carcinoma

Hepatic carcinoma is the sixth most common malignancies and the third most common cause of cancer deaths worldwide. Sepantronium bromide, a small molecule survivin inhibitor that has broad-spectrum anticancer therapeutic activities in various xenograft models, has broad-spectrum anticancer therapeutic effects. With effective targeting for homologous HC cells, superior biocompatibility, and favorable immunocompatibility for in vivo applications, the Cytomembrane coating endowed iM7721@GQD-YM with optimum targeting for clone-based coating, excellent biocompatibility, and good immunocompatibility for in vivo use. Surface decoration of an iRGD peptide has also improved tumor targeting activity by iRGD-integrin recognition. In addition, GQDs can directly kill tumors under the irradiation of near-infrared ray causing cell membrane rupture and cause cell membrane rupture, effectively releasing YM155 at tumor sites.

Source link: https://ui.adsabs.harvard.edu/abs/2022NaRes..15.8255F/abstract


Two copper(II) compounds derived from tetrazole carboxylates for chemodynamic therapy against hepatocellular carcinoma cells

[Cu22193H2O and [Cu2]u22192H2O] were synthesised and synthesized by hydrothermal reactions, two Cu compounds based on tetrazole-carboxylate ligands, [Cu22193H2O and [Cu22192H2O]]u22192H2O] are synthesized and synthesized by hydrothermal reactions. Nanoprecipitation with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-2000] aids in the formation of the nanoparticles with good water disperity. The two NPs exhibit significant cytotoxicity toward human hepatocellular carcinoma cells with low half-maximal inhibitory concentrations, according to the In vitro study.

Source link: https://ui.adsabs.harvard.edu/abs/2022FrCh...10.5247S/abstract


Raman spectroscopy and machine learning for the classification of esophageal squamous carcinoma

Early diagnosis of esophageal squamous cell carcinoma, a common malignant tumor with a low overall survival rate due to metastasis and recurrence, is crucial for safe diagnosis and improved prognosis. Through Raman spectroscopy, seven ESCC cell lines and tissues of an ESCC patient with staging of T3N1M0 and T3N2M0 at low and high differentiation rates were investigated. Four machine learning algorithms were used, including principal components analysis - linear discriminant analysis, PCA-eXtreme gradient boosting, PCA-support vector machine, and a PCA-stacked Gradient Boosting Machine, according to Raman spectral data analysis. Four machine learning algorithms were able to distinguish ESCC cell subtypes from normal esophageal cells. This review outlined the Raman spectral characteristics of ESCC cell lines and esophageal tissue samples related to clinical pathological diagnosis. Future studies should investigate the role of Raman spectral characteristics in ESCC pathogenesis.

Source link: https://ui.adsabs.harvard.edu/abs/2022AcSpA.28121654H/abstract


Evaluation of nitroreductase activity in nasopharyngeal carcinoma progression by an activatable two-photon fluorescent probe

NTR levels in hypoxic tissues or cells and tumors, according to previous reports, have risen in comparison to the normal state, and they were positively linked to hypoxia. We developed NaT-NTR, a two-photon fluorescent probe, for the testing of NTR in nasopharyngeal cell lines and tissues of various hypoxia levels, as mentioned above. In addition, imaging NTR in various cell lines revealed that the presence of intracellular NTR could be positively correlated with nasopharyngeal carcinoma malignancy.

Source link: https://ui.adsabs.harvard.edu/abs/2022AcSpA.28121616Z/abstract


A hemicyanine-based fluorescent probe for simultaneous imaging of Carboxylesterases and Histone deacetylases in hepatocellular carcinoma

A remarkable rise with a NIR emission at 720 nm, a low detection threshold for HDAC1, HDAC6, CES1 and CES2, as well as a high selectivity for the target enzymes over other important analytes was shown by Lys-HXPI. In addition, Lys-HXPI was used to image endogenous target enzymes in living cells, tumor-bearing nude mice, and tissue slices. In Hep G2 and MDA-MB-231, the ability of Lys-HXPI to simultaneous image CESs and HDACs was demonstrated by RT-qPCR and confocal imaging. The probe was also used to photograph Hep G2 tumor mice and tissue slices using NIR emission, which was also useful in imaging Hep G2 tumor mice and tissue slices.

Source link: https://ui.adsabs.harvard.edu/abs/2022AcSpA.28121529S/abstract


Lightweight Compound Scaling Network for Nasopharyngeal Carcinoma Segmentation from MR Images

Nasopharyngeal carcinoma is a group of tumours with a high prevalence in head-and-neck. Doctors invariably need to perform focal segmentation in order to diagnose nasopharyngeal cancer. We recommend a new LW-UNet network to help small and medium-sized hospitals with limited computational capabilities to operate the model efficiently and improve structure's accuracy. The network converts lightweight modules to create the Compound Scaling Encoder, which makes the model both light and accurate, while UNet brings the benefits of UNet.

Source link: https://ui.adsabs.harvard.edu/abs/2022Senso..22.5875L/abstract


Activation of nano-photosensitizers by Y-90 microspheres to enhance oxidative stress and cell death in hepatocellular carcinoma

In vitro, the aim of this research was to determine whether Y-90 microspheres in vivo enhance hepatocellular carcinoma cell oxidation and cytotoxicity in vitro, as well as cytotoxicity over Y-90 microspheres. HCC cells from SNU-387 and HepG2 were significantly reduced in viability when treated with low-activity Y-90 microspheres and a nano-photosensitizer composed of either titanium dioxide and titanocene labelled with transferrin compared to Y-90 microspheres alone or untreated cells. A linear dependence on Y-90 at higher rates was demonstrated by increasing TiO 2 -Tf-TC concentrations in the poorly differentiated SNU-387 HCC cell line but not in the well differentiated HepG2 cell line. In the presence of Y-90, TiO 2 -Tf-TC supplemented normal human hepatocyte THLE-2 cells did not increase cellular oxidation stress or cell death.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1212748M/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions