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Carcinoid Syndrome - Crossref

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Last Updated: 10 January 2023

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Value of a patient-reported-outcome measure of carcinoid syndrome symptoms

Objective Literature on patient-reported outcomes of carcinoid syndrome disorders is sparse. We used a patient-reported success questionnaire to determine CSS, the key aspects of daily life affected by CSS, the key signs that influence daily life, its evolution according to medical, biological, and morphological evolution, as well as the risk factors for a low PRO-CSS score. The goal was an above-label dose of somatostatin analogues in total, 147 patients with metastatic ileal, lung, or unknown primitive neuroendocrine tumor; however, high 5-hydroxyindole-3-acetic acid level was present; 42 patients with metastatic ileal, lung, or unknown primitive neuroendocrine tumour were identified; 42 were given an above-label dose of somatostatin analogues. Patients with a low PRO-CSS score had a higher tumor burden. Conclusions: PROM-CSS will help physicians make an objective assessment of CSS and its effects in daily life; this tool may be a key evaluation criterion in clinical trials focusing on CSS.

Source link: https://doi.org/10.1530/eje-20-1138


The syndrome of gastric carcinoid and hyperparathyroidism: a family study and literature review

Objectives: To support the belief that the coexistence of gastric carcinoids and hyperparathyroidism may be a distinct clinical entity, not related to multiple endocrine neoplasia types 1 and 2. Over a mean follow-up period of 31. 2 months, all siblings underwent serial gastroscopies for the determination of gastric neuroendocrine cell proliferations. Four of the siblings, all male, were found to have GCs in a background of Helicobacter pylori-associated chronic atrophic gastritis and pervasive anaemia with no clinical evidence of gastric autoimmunity. Screening for MEN1 gene mutations or large deletions was negative, and hormone and imaging studies did not support a diagnosis of familial MEN1 syndrome. In patients with GC of any kind, screening for hyperparathyroidism seems to be justified.

Source link: https://doi.org/10.1530/eje-08-0867


Tachykinins in endocrine tumors and the carcinoid syndrome

In patients with metastasizing ileocecal serotonin-producing tumors, a new antibody, active against the common tachykinin C-terminal, was used to investigate TK expression in patients with endocrine tumors and a potential relationship between plasma-TK levels and diarrhea and flush in patients with metastasizing ileocecal serotonin-producing carcinoid tumors. In 42 patients with MSPCs before treatment and symptoms in patients with the carcinoid syndrome, circulating TK and urinary-5 hydroxyindoleacetic acid levels were determined. CgA levels were also determined in 39 out of the 42 patients. The association of P-TK with daily diarrhea was independent of both U-5HIAA and CgA scores, according to a Spearman partial rank test. Conclusions We found that TK synsynthesis occurs in serotonin-IR tumors and that P-TK levels are strongly related to symptoms of flushing and diarrhea in patients with MSPCs.

Source link: https://doi.org/10.1530/eje-08-0196


RT-PCR analysis of corticotroph-associated genes expression in carcinoid tumours in the ectopic-ACTH syndrome

Expression of the Tpit and Pitx1 gene in ACTH-positive tumors was not limited to ACTH-positive tumors, but they were also present in several ACTH-negative carcinoids. In every tumor, the glucocorticoid receptor alpha was found in every tumor, in contrast to its beta isoform detectable in a few tumours only. In half of each group's tumours, chicken ovalbumin upstream promoter-transcription factor 1 and peroxisome proliferator-activated receptor u03b32 were present, whereas PPAR-u03b31 was present in almost every tumour. Conclusions: ACTH-positive carcinoids do not have a characteristic expression pattern of the corticotroph-associated transcription factor genes, meaning that transcriptional functions of the ACTH-precursor gene differ from those in normal pituitary corticotrophs. Some aspects of the pituitary corticotroph phenotype may be related to general carcinoid differentiation, according to the expression of Tpit and Pitx1 genes in most carcinoids.

Source link: https://doi.org/10.1530/eje.1.02077


[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) positron emission tomography imaging of thymic carcinoid tumor presenting with recurrent Cushing’s syndrome

The findings of inferior petrosal sinus sampling after coricotropin-releasing hormone stimulation were suggestive of pituitary ACTH hypersecretion, in a young woman with Cushing's syndrome, in whom endocrine studies and negative pituitary imaging were ectopic ACTH stigmatization. Thymectomy revealed concomitant ectopic CRH and potential ACTH formation by a thymic neuroendocrine carcinoma. A repeat [18 F]FDG PET study showed persistent disease in the thymic bed as well as adrenal overgrowth. A new [18 F]FDG PET scan 8 months later showed no development of the thymic tumor and announced complete excision of the adrenals. This is the first instance of concomitant CRH and ACTH secretion from a thymic carcinoid tumor, and it illustrates the effectiveness of functional imaging in the diagnosis, and follow-up of neuroendocrine tumors.

Source link: https://doi.org/10.1530/eje.1.01839


Use of In-111 pentetreotide scintigraphy in the diagnosis of a midgut carcinoid causing Cushing's syndrome

With high dose dexamethasone, biochemical experiments showed partial inhibition of urinary free cortisol. Two 'hot' lesions in the abdomen were then confirmed by subsequent directed thin-slice abdominal CT and a small bowel barium study, which were followed by single photon emission computerized tomography. Histopathology was consistent with a malignant carcinoid tumor of the ileum, which stained notably for ACTH. Plasma ACTH, serum and urinary cortisol, and serum and urinary cortisol normalized postoperatively. This is the first reported case of ileal carcinoid tumor causing Cushing's syndrome with premortem diagnosis, according to our knowledge.

Source link: https://doi.org/10.1530/eje.0.1370079


Diagnosis and radioguided surgery with 111In-pentetreotide in a patient with paraneoplastic Cushing's syndrome due to a bronchial carcinoid

The biopsy pinpointed the tumor to the right inferior chest lobe, with a tumor/normal tissue count ratio of 6:1 and a tumor/hilar normal lymph node ratio of 12:1, allowing the complete removal of the tumor without excluding lymph node and/or parietal involvement. The 111 In-OCT was shown to be effective in localizing the ACTH-covered tumor and enabling rapid non-invasive differential diagnosis between an ACTH-secreting pituitary adenoma and malignancy syndrome causing ectopic ACTH syndrome. This research also demonstrated the clinical effectiveness of radioguided surgery in the treatment of bronchial carcinoid.

Source link: https://doi.org/10.1530/eje.0.1370688


Guillain–Barré Syndrome in a patient with systemic lupus erythematosus with underlying pituitary carcinoid: A rare presentation

History: Guillain-Barru00e9 syndrome is a rare neuropsychiatric complication of systemic lupus erythematosus. Individuals with SLE have distinct characteristics than those without SLE. To the best of our knowledge, GI carcinoid coexisting with SLE has only been identified once, and coexistent GBS and SLE with pituitary carcinoid have never been reported before. Greater understanding of how inflammation contributes to cytological changes that lead to the development of a carcinoid may help to investigate newer pathologic mechanisms and therapies. Conclusion: A slew of symptoms including GBS can be present in patients with SLE and neuropsychiatric disorder, including GBS. Recognizing such rare presentations and assessing the likelihood of a carcinoid tumor in the presence of signs such as intermittent palpitation, dizziness, profuse sweating, and flushing could alert the physician of underlying carcinoid tumor that may be dangerous if left untreated.

Source link: https://doi.org/10.12982/jams.2023.012


Biochemical factors in the blood serum of neuroendocrine tumor patients with carcinoid syndrome

Carcinoid syndrome is the most common functional disorder in patients with neuroendocrine tumors. The study of biochemical markers of carcinoid syndrome and related carcinoid heart disease in neuroendocrine tumor patients is an important goal of laboratory investigation in neuroendocrine tumor patients. In 43 patients, a clinic of carcinoid syndrome was found, 16 of them had signs of carcinoid heart disease. In comparison to G1 and G2, the median PDGF-BB in patients with G3 tumors was statistically significant higher than in controls. ProBNP had the highest diagnostic sensitivity in patients with carcinoid syndrome, serotonin and chromogranin A, although in patients with a CAD clinic, it was the highest sensitivity u2013 93. 8 percent. PDGF-BB's highest levels are associated with a high risk of neuroendocrine tumor malignancy in the United States.

Source link: https://doi.org/10.17650/2313-805x-2022-9-4-71-77

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions