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Carcinogenicity - Springer Nature

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Last Updated: 10 September 2022

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No evidence for carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

Exposure to TiO_2 NPs, as well as other organs, did not raise the incidence of lung tumors in any group, and pulmonary fibrosis and pre-neoplastic lesions were not present in any groups. Lastly, the cell proliferative capacity of alveolar epithelial type 2 cells was found, but not enhanced by TiO_2 NP exposure. This is the first study to reveal the absence of pulmonary fibrogenicity and carcinogenicity of TiO_2 NPs in a 26-week inhalation experiment in rasH2 mice exposed up to 32 mg/m3, which is considered a high dose.

Source link: https://doi.org/10.1038/s41598-022-19139-y

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions