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Carcinogenic - Springer Nature

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Last Updated: 10 January 2023

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Non-carcinogenic/non-nephrotoxic aristolochic acid IVa exhibited anti-inflammatory activities in mice

Despite the active pharmaceutical ingredients remaining unclear, Aristolochic acid containing herbs have been used as anti-inflammatory drugs for thousands of years. In our study and other studies, AAIVa, an analogue abundant in AA-containing herbs, showed neither carcinogeny nor nephrotoxicity, suggesting that the pharmacological effects of AAIVa on inflammation are worth investigating. Our findings showed that AAIVa could reduce pro-inflammatory cytokines production in LPS-stimulated RAW 264. 7 cells, showing its anti-inflammatory activity in vitro. Moreover, the use of AAIVa could potentially reduce phorbol 12-myristate 13-acetate-induced ear edema, demonstrating its vivo-topic anti-inflammatory activity. In TNF-IRES-Luc mice, a single dose of AAIVa could reduce LPS-induced inflammation by lowering luciferase activity of TNF-u03b1. In addition, the online pharmacological databases predicted that AAIVa would target T cell activation-related protein regulation for anti-inflammatory activity.

Source link: https://doi.org/10.1007/s11418-022-01665-8


Zearalenone and its metabolite exposure directs oestrogen metabolism towards potentially carcinogenic metabolites in human breast cancer MCF-7 cells

Zearalenone is produced by Fusarium species contaminating several agriculture crops. The effects of ZEN and its metabolites, u03b1-zearalenol, and u03b2-zearalenol were investigated in this study, as well as u03b1-zearalenol and u03b2-zearalenol and u03b2-zearalenol, a vivin oestrogen-catechols (MCF-7 cells' formation of carcinogenic oestrogen-catechols zea zeacellular metabolites tu03b1-zearalenotu03b1-zearalenozèaralenotu03b3b03b1-zea03b2-zea03b1-zea03b1-zeadea03b1-zearalenoea03b3b1-zearalenool a76-zearithenotearalenovesca-zearylen-b1-zeaprostatin MCF-7 cell-catechol To investigate the effects of mycoestrogens on the formation of cytochrome P450 1A1 and CYP1B1, the rate of ethoxyresorufin O-deethylation was determined. Mycoestrogens reduced CYP 1A1 and increased CYP 1B1 expression in the presence of selective inhibitors, which enhanced CYP 1A1 and increased CYP 1B1 production in the presence of selective inhibitors. The upregulation of AhR and confirmed the selective action of mycoestrogens on CYP1 expression levels and the decline of the CYP 1B1 ratio showed the increase of the CYP1 expression levels and the decrease of the CYP 1A1/CYP 1B1 ratio.

Source link: https://doi.org/10.1007/s12550-022-00472-0

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions