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Carcinogenic - Europe PMC

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Last Updated: 10 September 2022

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Applicability of a Host-mediated In Vivo / In Vitro Model in Screening for the Carcinogenic Potential of Chemicals.

Based on a journal published by Tomasetti and Vogelstein in 2015, in which the risk of cancer outbreaks is estimated to be just one-third due to genetic predisposition and environmental causes, it was worth focusing once more on the importance of testing chemicals for their carcinogenicity. The results and benefits of host-mediated in vivo/in vitro assays in general have been compared to in vitro and in vitro tests, respectively.

Source link: https://europepmc.org/article/MED/36039418


A Pan-Cancer Analysis of SRD5A1, a Potential New Carcinogenic Indicator Related to Immune Infiltration and Prognosis of UCEC

SRD5A1 ex p ression was variablely and higher p rediculted worse survival rates in the majority of tumor sam p les. Ex p ression of T cell migration and immune check p oints was highly related to SRD5A1 ex p ression. In several cancers, there were strong links between SRD5A1 ex p ression and tumor mutation burden, or microsatellite instability. In the majority of cancers, high SRD5A1 levels were related to the infiltration of myeloid-derived su p ressor cells and Th2 subsets of CD4+ T cells. InUCEC, we finally established the p an-cancer SRD5A1 ex p ression and its im p act on immune infiltrate. SRD5A1 may synergize with other immune check p rognosis in p an-cancer es p rognosis, es p ecially UCEC, and may shed new light on the r eutics of cancer in clinicians.

Source link: https://europepmc.org/article/PPR/PPR535529


Artificial intelligence uncovers carcinogenic human metabolites.

Despite the availability of natural DNA damage responses, certain genetic lesions cause cell mutations that cause malignant cell mutation. Metabokiller is completely understandable and outperforms current best-practice techniques for carcinogenicity estimation, according to Conditant's carcinogenicity forecast. Metabokiller deciphered potential carcinogenic human metabolites. We conducted multiple functional assays with Saccharomyces cerevisiae and human cells, including 4-nitrocatechol and 3,4-dihydroxyphenylacetic acid, resulting in high synergy between Metabokiller predictions and experimental validations, resulting in high synergy between Metabokiller predictions and experimental validations. To cross-validate Metabokiller predictions, we developed multiple functional assays using Saccharomyces cerevisiae and human cells.

Source link: https://europepmc.org/article/MED/35953549

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions