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Carcinogenic - Crossref

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Last Updated: 10 August 2022

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Determination of carcinogenic primary aromatic amines contained as impurities in synthetic organic colorants

Several forms of PAAs may occur either by the reduction of azo compounds or as impurities in azo colorants or other agents. Nearly all PAAs were found to be starting materials for colorant synthesis, except for phenolylazoaniline in Yellow No. 3. P-phenylazoaniline was found in all samples at concentrations ranging from 88 to 370 bcg/g, with notable traces from five manufacturers. Conclusions A method to analyze such PAAs that were embedded as impurities in synthetic organic colorants was developed, and the actual status of them in colorants was clarified. Highlights from this report The analytical method used in this research for the determination of certain PAAs that were identified as impurities in synthetic organic colorants may be used to enhance colorants' safety.

Source link: https://doi.org/10.1093/jaoacint/qsac095


Evaluation of the Carcinogenic Potential of Roxadustat (FG-4592), a Small Molecule Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase in CD-1 Mice and Sprague Dawley Rats

HIF-PH secreta byroxadustat causes a rapid rise in cytoplasmic HIF-u03b1 concentrations, followed by relocation of HIF-u03b1 to the nucleus and the re-regulation of HIF-responsive genes, including erythropoietin. Changes in hematocrit, hemoglobin, hematocrit, and red cell distribution width in rats at 10 mg/kg TIW were consistent with pharmacologic activity of roxadustat and included rises in hematocrit, hemoglobin, hematocrit, and red cell distribution width in rats at 30 and 60 mg/kg TIW. In conclusion, roxadustat administered by oral gavage to mice and rats TIW for up to 104 weeks resulted in dose-dependent exposure and hematologic consequences with no effect on mouse or rat survival or development of neoplastic lesions.

Source link: https://doi.org/10.1177/1091581817737232


BPS and BPF are as Carcinogenic as BPA and are Not Viable Alternatives for its Replacement

Despite the benefits offered by the material, conventional plastic has negative impacts on the climate and human health. Objectives: The researchers wanted to conduct a new study on BPA's damaging effects on human health, focusing on the carcinogenicity of the drug's harmful effects on human health, evaluating the behavior of action, as well as its analogs' effects, and finding if BPS and BPF are viable alternatives to BPA's substitution in plastic polymers' replacement. Methods: Methods were detailed in this review, with results that were collected and updated with precision in this study. BPA has a high carcinogenic potential, with established causes to cause breast, ovarian, prostate, cervical, and lung cancers, elucidating that its analogs are also xenoestrogens and cannot be considered as viable alternatives for its replacement.

Source link: https://doi.org/10.2174/1871530322666220316141032


Occurrence of Carcinogenic illudane Glycosides in Drinking Water Wells

This report investigates the presence of PTA, CAU, PTE, and their corresponding hydrolysis products pterosins B, A, and G in water wells in Denmark, Sweden, and Spain. Water samples from deep groundwater wells and shallow water wells were collected and stored in the field, pre-concentrated in the lab, and analysed by liquid chromatography-mass spectrometry. However, seven private shallow wells contained at least one of the illudane glycosides and/or pterosins at concentrations up to 0. 27 % L-1 and 0. 28 g L-1, 0. 03 u00b5g L-1, 0. 75 % g L-1, 0. 30 u00b5g L-1, 0. 32 u00b5g L-1, 0. 26 u00b5g L-1, 0. 03 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g L-1 u00b5g l-1 u Conclusions Detected traces of illudane glycosides in several of the test wells exceeded the intended maximum tolerable concentrations of PTA, although they were intended for drinking water purposes. Contaminated wells were characterized by shallow depth, lower pH, and electrical conductivity compared to deep groundwater wells, where no illudane glycosides or pterosins were discovered.

Source link: https://doi.org/10.21203/rs.3.rs-103108/v1


Diagnostic significance and carcinogenic mechanism of pan-cancer gene POU5F1 in liver hepatocellular carcinoma

POU Class 5 Homeobox 1's prognostic and clinicopathological importance among various cancers is uncertain heretofore. POU5F1's diagnostic value and function mechanism in liver hepatocellular carcinoma have yet to be investigated thoroughly. qPCR in plasma obtained from LIHC patients and controls was used to determine POU5F1's expression and diagnostic value. CIBERSORT reported the relationship between POU5F1 and tumor infiltrating immune cells in LIHC. The combination of POU5F1 and AFP in plasma provided high diagnostic reliability. In particular, POU5F1's level was correlated with infiltrating levels of B cells, T cells, dendritic cells, and monocytes in LIHC. POU5F1 was involved in numerous cancer-related pathways and cell proliferation pathways, according to GSEA. POU5F1's study found that it was not only a prognostic and diagnostic biomarker in several cancers, especially in LIHC, but also functionally carcinogenic in LIHC.

Source link: https://doi.org/10.21203/rs.3.rs-51170/v1


IPSE, an Abundant Egg-Secreted Protein of the Carcinogenic Helminth Schistosoma haematobium, Promotes Proliferation of Bladder Cancer Cells and Angiogenesis

Despite the causal association of S. haematobium and bladder cancer, the underlying mechanisms are not well understood. Angiogenesis and urothelial hyperplasia have been correlated with angiogenesis and urothelial hyperplasia in the bladder. Methods: Mouse bladders treated with S. haematobium eggs were analyzed by microscopy for angiogenesis and urothelial hyperplasia. Cell lines were cultured with recombinant IPSE protein or an IPSE mutant protein that lacks the native nuclear localization sequence and proliferation were incubated with endothelial and urothelial cell lines, as well as real-time cell growth monitoring. Findings: Injection of S. haematobium eggs into the bladder initiates angiogenesis, increases leakiness of bladder blood vessels, and promotes urothelial hyperplasia. The Wild type IPSE, but not NLS-, promotes endothelial and urothelial cells proliferation, as well as skews urothelial cells into S phase, as well as NLS-. IPSE, therefore, is a candidate pro-carcinogenic molecule of S. haematobium.

Source link: https://doi.org/10.21203/rs.3.rs-40784/v2


IPSE, an Abundant Egg-Secreted Protein of the Carcinogenic Helminth Schistosoma haematobium, Promotes Proliferation of Bladder Cancer Cells and Angiogenesis

Abstract Background: Schistosoma haematobium, the helminth that causes urogenital schistosomiasis, is a well-known bladder carcinogen. Despite the causal association between S. haematobium and bladder cancer, the underlying mechanisms are unclear. Angiogenesis and urothelial hyperplasia are both associated with bladder oviposition in the bladder in the S. haematobium. Methods: Mouse bladders treated with S. haematobium eggs were analyzed by microscopy for angiogenesis and urothelial hyperplasia. Endothelial and urothelial cell lines were incubated with either recombinant IPSE protein or an IPSE mutant protein that lacks the native nuclear localization sequence and proliferation were measured using CFSE staining and real-time monitoring of cell growth. Findings: Injection of S. haematobium eggs into the bladder stimulates angiogenesis, increases bladder blood vessel leakage, and promotes urothelial hyperplasia. The wild type IPSE, but not NLS-, increases the proliferation of endothelial and urothelial cells, as well as skews urothelial cells towards S phase. IPSE, by definition, is a candidate pro-carcinogenic molecule of S. haematobium.

Source link: https://doi.org/10.21203/rs.3.rs-40784/v1

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions