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Carcinogen - U.S. Department of Veterans Affairs

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Last Updated: 10 September 2022

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RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.

We found that RNF144A-deficient mice are more susceptible to bladder tumor formation after carcinogen exposure, according to this study. RNF144A interacts with PD-L1 in the plasma membrane and intracellular vesicles, resulting in polyubiquitination and degradation of PD-L1. Therefore, Rnf144a KO stabilizes PD-L1 and contributes to a decrease in tumor-infiltrating CD8+ T cell populations in the BBN-induced bladder tumors. BBN-induced bladder tumor tumors are primarily characterized by CK5 and CK14 in WT and Rnf144a KO mice, which are primarily indicative of basal cancer subtypes. Such disparities in Rnf144a KO tumors likely resulted from a decrease of EGFR expression, consistent with the reported role of RNF144A in maintaining EGFR expression. In summary, the RNF144A gene suppressor activity after carcinogenic insult is shown in vivo tumor suppressor activity on in vivo tumor suppressor activity.

Source link: https://doi.org/10.1016/j.canlet.2021.08.008

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions