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Carcinogen - Europe PMC

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Last Updated: 10 September 2022

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Organophosphonic Acid-Regulating Assembly of P V -Sb III Polyoxotungstate and Its Potential in Building a Dual-Signal Readout Electrochemical Aptasensor for Carcinogen Detection.

Template-directed assembly of massive cluster-based nanomaterials is a long-running cluster science trend. Organophosphonic acid ligand not only serves as an organic template leading to the manufacture of a [HEDTPASbW 15 O 50] 14-block building block but also crosses the sandwich-type [CeW 4 O 10 2 ] 11- entity, but also extends the sandwich-type [CeW 4 O 10 2 ] 11-body. In addition, the 1 @EGO composite was tested as a glassy carbon electrode precursor to develop a dual-signal electrochemical aptasensor for carcinogens, which results in higher detection results for aflatoxin B1 compared to conventional single-signal biosensors.

Source link: https://europepmc.org/article/MED/36073797


Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1.

Several intrinsic signaling pathways influence Indoleamine 2,3-dioxygenase 1, the enzyme that promotes tryptophan metabolism to promote regulatory T cells and suppress CD8+ T cells. In NSCLC patients, smokers with lower IDO1 levels responded better to anti-PD1 antibody therapy than those with higher IDO1. These results show that tobacco smoke causes IDO1 to catabolize Trp metabolism and immune suppression to promote carcinogenesis, and lower IDO1 can be a potential biomarker for anti-PD1 antibodies in smokers, while IDO1-positive smokers can benefit from IDO1 inhibitors in combination with anti-PD1 antibodies.

Source link: https://europepmc.org/article/MED/36068203


Prevention of carcinogen-induced oral cancers by polymeric black tea polyphenols via modulation of EGFR-Akt-mTOR pathway.

In the hamster model of oral carcinogenesis, the chemopreventive potential of polymeric black tea polyphenols/thearubigins is investigated, as well as the effects of PBPs on EGFR and molecular participants in the EGFR pathway. Pre and concurrent PBP therapy with PBPs reduced the number and number of macroscopic tumors, as well as the number and location of microscopic lesions in a dose-dependent manner. PBPs' preclinical chemopreventive activity, as well as a glimpse at its mechanistic role in experimental oral cancer chemoprevention.

Source link: https://europepmc.org/article/MED/36008552

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions