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Carcinogen - DOAJ

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Last Updated: 10 September 2022

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Chromatographic Detection of 8-Hydroxy-2′-Deoxyguanosine in Leukocytes of Asbestos Exposed Workers for Assessing Past and Recent Carcinogen Exposures

The mechanism that leads to asbestos's carcinogenic effect has not been fully understood by underlying systems that are behind the carcinogenic effect of asbestos. 8-hydroxy-2'u2032-deoxyne, one of the most useful biomarkers of oxidative stress and oxidative DNA damage, has been studied in the peripheral blood of people in Tuscany and Liguria regions; Italy; stratified by occupational exposure to this drug. The prevalence of 8-oxodG per 10 5 deoxygyl workers exposed to the controls was noticeably higher among exposed workers with respect to the safety procedures, with a score of 1. 3 0. 1 in unexposed controls; i. e. , 0. 3 %u00b1 0. 1. For the identification of subjects requiring more rigorous medical monitoring, 8-oxodG can be used for medical surveillance of cohorts of workers with previous and recent exposures to carcinogens for cohorts of employees with past and recent exposures to carcinogens.

Source link: https://doi.org/10.3390/diagnostics10040239


ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice

Enterotoxigenic E. coli-producing heat-stable enterotoxins are common in developing countries, including enterotoxigenic E. coli that produce heat-stable enterotoxins. STs are peptides that are structurally similar to intestinal cyclase C receptors that regulate the intestinal cyclase C receptor. In part, the geographic disparity in colorectal cancer may have reflected persistent exposure to ST-producing organisms that restore GUCY2C signaling silenced by hormone loss during transformation. Here, mice raised for 18 weeks with control E. coli or those engineered to conceal ST exhibited normal growth, with similar weight gain and normal stool water content, but no evidence of deception diarrhea. In addition, mice colonized with ST-producing E. coli showed a 50 percent decrease in carcinogen-induced colorectal tumor burden. In other words, chronic colonization with ETEC-producing ST could lead to endemic cancer risk in developing nations, reintroducing a new model of colorectal cancer therapy with oral GUCY2C-targeted agents.

Source link: https://doi.org/10.3390/toxins9090279


Approval Research for Carcinogen Humic-Like Substances (HULIS) Emitted from Residential Coal Combustion in High Lung Cancer Incidence Areas of China

The incidence and mortality rate of lung cancer in Xuanwei County, Yunnan Province, China, is among the highest in the Chinese province. However, in Xuanwei, the particle size distribution characteristics of HULIS emitted from residential coal combustion have yet to be investigated. According to our analysis, the ratio of HULIS-Cx to WSOCx values in RCC particles was 32. 73 percent for PM 2. 0 and 33. 91% for PM 2. 07. 0, respectively. Expliciting the HULIS content and particle size distribution of the particulate matter caused by household coal combustion provides a new perspective and data for determining the high incidence of lung cancer in Xuanwei, China.

Source link: https://doi.org/10.3390/pr9071254


Early and late genome-wide gastric epithelial transcriptome response during infection with the human carcinogen Helicobacter pylori

Helicobacter pylori bacteri infection of the stomach is a significant risk factor for gastric cancer development. H. pylori wt, but not u0394htrA bacteria, which were primarily localized at cellular junctions, was found in fluorescence microscopy. According to H. pylori CagA expression, infection with the u0394htrA mutant raised apoptosis rates in host cells. H. pylori is the product of many carcinogenesis-related genes, affecting transcription of various carcinogenesis-related genes in contrast to H. pylori unrelated to HtrA.

Source link: https://doi.org/10.1016/j.cellin.2022.100032


Potential of Kale and Lettuce Residues as Natural Adsorbents of the Carcinogen Aflatoxin B 1 in a Dynamic Gastrointestinal Tract-Simulated Model

To figure out the interaction mechanisms between the AFB 1 molecule and the biosorbents, various characterization techniques were used. Based on adsorption test results, the biosorbent prepared from kale was the best; its maximum adsorption capacity was 93. 6%, more than that of the lettuce biosorbent; the sorbent was 93. 6%. The key driving factors behind AFB 1 biosorption appear to be non-electrostatic and electrostatic interactions, as well as the establishment of AFB 1 -chlorophyll complexes, which appear to be the key influencing factors driving AFB 1 biosorption.

Source link: https://doi.org/10.3390/toxins13110771


Prevention of carcinogen-induced oral cancers by polymeric black tea polyphenols via modulation of EGFR-Akt-mTOR pathway

Abstract The overexpression of Epidermal Growth Factor Receptor and dysregulation of its downstream effector pathways are two important molecular hallmarks of oral cancers. The present study explores the chemopreventive potential of polymeric black tea polyphenols/thearubigins in the hamster model of oral carcinogenesis as well as the effect of PBPs on EGFR and the molecular participants in the EGFR pathway. Our findings, taken together, reveal preclinical chemopreventive activity of PBPs and provide an insight into its mechanistic involvement in experimental oral cancer chemoprevention.

Source link: https://doi.org/10.1038/s41598-022-18680-0

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions