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This review integrates recent published toxicogenomics results to determine how exposure to a single rat chemical carcinogen improved liver transcriptomic changes at various life cycle stages. We found that at all three life cycle stages, PBDE exposure induced hepatocellular transcriptionomic changes in disease pathways including cancer, metabolic, membrane function, and Nrf2 antioxidant pathways, pathways all typical of chemical carcinogens. The results of liver transcript changes characteristic of carcinogenic exposures and short-term adult exposures have been published in model studies, supporting the use of transcriptomic results to determine the apical cancer endpoints. Knowing results from gene expression profiling studies after neonatal, young, or adult short-term chemical exposure help to achieve the 21st century toxicology goal of designing research plans to minimize, refine, and replace the use of traditional 2-year rodent cancer studies to provide hazard identification information.
Source link: https://doi.org/10.3389/ftox.2022.1028309
In a mouse carcinogen-induced tumor model, we investigate if altering lung microbiota, which contribute to immunosuppression, by antibiotics or probiotic aerosol interferes with lung cancer formation. Live or heat-killed L. RGG reduced Tumor nodules number, diameter, and area, while only a decrease in nodule diameter was observed in V/N-treated lungs, leading to a decrease in nodule diameter and area. Both L. RGG and V/N lowered Tregs in the lung. The gene encoding the joining chain of immunoglobulins was increased in L. RGG-treated groups, and J chain protein and IgA levels were observed. High levels of J chain mRNA and good prognosis in lung adenocarcinoma patients were correlated with elevated B and CD4 T cells, reduced Tregs and M2 macrophages, according to a study by Kaplan u2013Meier plotter. This report discusses L. RGG aerosol efficacy in suppressing lung cancer growth by raising local immunity and pointing to this non-invasive approach to treat individuals at risk of lung cancer.
Source link: https://doi.org/10.3390/ijms232112748
Background: Occupational cancer is a worldwide health problem. CARcinogen EXposure – a database of CARcinogen EXposure – was designed for the Korean labour force to determine the number of workers exposed to carcinogens by industry. The present research sought to determine the severity of exposure to carcinogens by industry in order to provide further insight into CARcinogen EXposure intensity to the K-CAREX. Methods: Based on the K-CAREX list, we used nationwide workplace monitoring data from 2014 to 2016 to find target carcinogens based on the K-CAREX list. We divided the CARcinogen EXposure intensity into five exposure ratings for each industry based on the 95th percentile threshold relative to the occupational exposure limit. The results: In each of the 228 minor industry groups, the exposure ratings were estimated for 21 carcinogenic agents. Conclusions: We reviewed the CARcinogen EXposure ratings in Korean workers' industries.
Source link: https://doi.org/10.1016/j.shaw.2022.05.003
Abstract Bladder cancer is the most common malignancy of the urinary system, with increasing incidence, mortality, and limited treatment options. We performed metabolomic profiling of premalignant and non-muscle invasive bladder cancer that developed in the chemical carcinogenesis N-butyl-N-nitrosamine mouse model. This is the first study describing the global metabolomic profiles associated with early pre-malignant and NMIBC, as well as providing the evidence that these metabolomic signatures can be used for diagnosis of human disease.
Source link: https://doi.org/10.1038/s41598-021-99746-3
To determine the interaction mechanisms between the AFB 1 molecule and the biosorbents, various characterization techniques were used. Based on adsorption testing results, the biosorbent prepared from kale was the best; its maximum adsorption capacity was 93. 6%, much higher than that of the lettuce biosorbent; based on adsorption results, the sorbent prepared from kale was the best; based on adsorption data, it was much higher than the lettuce biosorbent's. The key driving factors behind AFB 1 biosorption appear to be non-electrostatic and electrostatic interactions as well as the establishment of AFB 1 chlorophyll complexes.
Source link: https://doi.org/10.3390/toxins13110771
We've conducted an epidemiological investigation to determine the connection between 8-hydroxy-2-deoxygena, one of the most accurate biomarkers of oxidative stress and oxidative DNA damage, and asbestos exposure in residents of Tuscany and Liguria regions; Italy; stratified by occupational exposure to this drug. The prevalence of 8-oxodG per 10 5 deoxyanosine was elevated among exposed employees with respect to the controls, with a value of 1. 3 0. 1 in unexposed controls; i. e. , 3. 0 0. 1 in unexposed controls effected asbestos workers. respectively, 3. 2 0. 3 and 2. 9 0b1 respectively, respectively; when the correlation with occupational history was explored, significant 8-oxodG concentrations were found in current and former asbestos workers vs. healthy controls; 8-oxodG was determined in current and former asbestos workers vs. healthy controls; 3. 2 0. 3 0. 3 and 2. 9 0. 2 u00b1 0. 2 vs. 0. 2 u00b1 0. 2 u00b1 vs.
Source link: https://doi.org/10.3390/diagnostics10040239
In mice, chronic feeding of P-dimethylaminoazobenzene and phenobarbital was induced to see if a potentized homeopathic drug, Natrum Sulphuricum 200, has protective qualities against liver tumor formation. Mice were divided into five subgroups: fed a basic low protein diet; fed normal low protein plus alcohol 200; and fed diet and carcinogens like Gr. III, plus alcohol 200 and fed diet and carcinogens such as Gr. In Gr. , less than 60 percent of liver tumors were discovered.
Source link: https://doi.org/10.1093/ecam/nem067
Thyroid cancer is the most common endocrine disorder in the absence of a non-inhibitive agent. In two-day intervals for 30 weeks, male Sprague-Dawley rats were divided into four groups as Group-1; normally fed; DEN/MNU/DHPN care; Group-2; DEN/MNU/DHPN treatment only; Group-3 and -4; DEN/MNU/DHPN therapy; Group-2; only fed; Group-2; DEN/MNU/DHPN therapy; Group-2; normally fed; Group-1; Group-2; DEN/ The 3. 279 nmol/g in the IG group and 1. 752 nmol/g in the IP group were found to indicate that the average resveratrol concentration in thyroid tissues was 1. 278 nmol/g, and 1. 752 0. 398 nmol/g in the IP group. Group-3 and Group-4's final body weights were smaller than that of Group-1; but heavier than Group-2. In 53. 3 percent of Group-2; 33. 3% Group-3 and 26. 7% Group-4, TC-related lesions were discovered in 53 percent of Group-2; and 28. 7% Group-4. These findings show that IG and IP-based resveratrol reduces the incidence and severity of DEN/MNU/DHPN-caused TC-related lesions, which will be useful in thyroid tumor prevention.
Source link: https://doi.org/10.3390/nu10030279
Introduction: Skin cancer has risen day by day, but if skin cancer is detected early, it can be reversed. Reviewing the scientific literature on the 980 nm diode laser and its numerous benefits on skin diseases. In this paper, we investigated the effectiveness of this type of laser on the development of skin cancer in hamsters exposed to carcinogen on the back. During the experiment, none of the other groups that were exposed to diode 980nm laser irradiation at different speeds and an exposure time of 100 seconds showed no growth of skin cancer. Conclusion: The 980 nm Diode laser has a direct effect on delaying cancer formation and has played a role in skin cancer prevention.
Source link: https://doi.org/10.22038/ijmp.2018.30727.1354
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