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The addition of CMCS and ZnO improved the solvent resistance and UV shielding capabilities of the composite film, as well as increasing the application prospects of the film in water-rich foods. In addition, the combined film's synergistic action of CMCS and ZnO helped the composite film to effectively inhibit the pathogenic bacteria Listeria monocytogenes and Pseudomona aeruginosa in foods.
Source link: https://europepmc.org/article/MED/36623619
Since wound dressing has been regarded as a promising way to improve wound healing, recent research has been put on the development of new wound dressings based on synthetic and bioactive polymers. We created a multifunctional wound dressing based on carboxymethyl chitosan/sodium alginate hydrogel with a nanostructured lipid carrier in which simvastatin has been encapsulated in this study. The hydrogel composite with a filtration ratio of about 98. 44 % u00b1 31. 9 percent expansion and a 2116 g/m2. per day water vapor transfer rate among various fabricated composites of dressing demonstrated higher pore size and maintained wound moisture in comparison to other fabricated composites of dressing, including 707 % -u00b1 31. 9 percent increase and a 2116 g/m2. per day. The results revealed that this novel nanocomposite could be a promising candidate for treating various chronic wounds in skin tissue.
Source link: https://europepmc.org/article/MED/36603225
One of two novel macromolecular/microsphere-based injectable hydrogels with dual functionality of drug delivery and lubrication was developed by a flexible Schiff base crosslinking network between carboxymethyl chitosan and oxidation nanoparticles in the present study. CMC-ODex NPs hydrogels had low friction coefficients at the sliding interface of bovine articular cartilages, owing to boundary lubrication of hydrogel and the rolling friction effect of ODex NPs. In addition, the anti-inflammatory drug encapsulated in ODex NPs demonstrated stable drug release behavior during the dynamic shearing process, which gave CMC-ODex NPs hydrogels a good and stable anti-inflammatory effect.
Source link: https://europepmc.org/article/MED/36610563
This paper discusses our findings on the fabrication of a novel bioink from carboxymethyl chitosan and alginate for bioprinting scaffolds for enamel tissue regeneration. The printed scaffolds were extremely porous and showed a high degree of printability and structural stability, according to the results, the bioinks with higher concentrations of Alg were more viscous and needed more pressure for printing; the paper scaffolds were more porous and had a higher degree of printability and structural stability. After 14 d of culture in the 3D printed scaffolds, HAT-7 cells were also able to maintain their morphology and obscure alkaline phosphatase, demonstrating the cell's ability for mineral deposition and enamel-like tissue formation. In vitro, the highest likelihood of promoting ameloblast differentiation, Ca and P deposition, and matrix mineralization in vitro was found in all combinations Alg4%-CMC2% and in a lesser degree 2%Alg-4%CMC.
Source link: https://europepmc.org/article/MED/36583240
The aim of the study was to compare biopolymer CMCS hydrogels' properties and behavior with commercial ones in order to determine the right compositions for future research into wound-dressing applications. The elasticity of the gel was determined by component concentrations and the irradiation dose used to produce the hydrogel. The tested hydrogels' modulus was higher than that of the control material, with Youngu2019s modulus for the tested hydrogels being higher than that for the control material. No adverse effect of hydrogels on animal tissue was found by the biocompatibility studies, confirming their biocompatibility and indicating that CMCS hydrogels could be used as wound-healing dressings in the future. Ionizing radiation had been shown to be a reliable tool for CMCS hydrogel manufacture and could be useful in wound-healing therapy as it can also sterilize the product.
Source link: https://europepmc.org/article/MED/PMC9823898
The aim of the study was to determine the right compositions for future research into wound-dressing applications by comparing the structure and behavior of biopolymer CMCS hydrogels with commercial ones. Young's modulus for the tested hydrogels was higher than that for the control material. The analyzed hydrogels were not cytotoxic, according to the control, and at certain concentrations, they cause a small increase in the number of cells per cell. The biocompatibility studies that were carried out on laboratory rats showed no adverse effects of hydrogels on animal tissues, confirming their biocompatibility and implying that CMCS hydrogels could be used as wound-healing dressings in the future. Ionizing radiation was demonstrated to be a versatile device for CMCS hydrogel synthesis and could be useful in wound-healing therapy as it simultaneously sterilizes the product.
Source link: https://europepmc.org/article/MED/36616494
A porous silica coated with a pH-sensitive, biodegradable, and biodegradable polymer can be helpful in colon delivery. Porous silica was synthesized and sulfasalazine was added to it to investigate the release rate in simulated intestinal media. Porous silica was also functionalized by aminopropyltrimethoxysilane grafting and was investigated as a potential carrier for controlled drug delivery of sulfasalazine. No burst leak occurred in both coated and functionalized samples, and the swelling degree of coats in basic and neutral media reduced by the presence of alginate in the network, according to the researchers. It has been found that the coat with a 50:50 percent ratio would release the colon drugs in 24 h at a safe rate. Functionalization is also believed that functionalization was a key to drug uptake, but the rise in functionalized samples was lower.
Source link: https://europepmc.org/article/MED/36574135
Aim To determine the odontogenic differentiation potential of a composite scaffold made up of nanohydroxyapatite and carboxymethyl-chitosan with Biodentine on human dental pulp stem cells. Methodology (and Methodology) A CSHA scaffold was constructed using ultrasonication method by adding nHAp and CMC in the water medium and then freeze-drying. Following 7 and 14 days, Cell viability/proliferation and biomineralization capabilities of CSHA were compared to Biodentine assay, alkaline phosphatase production, Alizarin Red Staining, and osteopontin expression. Compared to day 7, CSHA significantly raised the VEGF and DSPP levels on hDPSCs on day 21. Unlike Biodentine, there are no statistical differences besides CSHA's that cell viability/proliferation persists for 14 days after CSHA, which is also supporting cell viability/proliferation over 14 days. However, CSHA's ALP and ARS activity soared with intense OPN staining compared to Biodentine after 14 days. Conclusions The results showed that the odontogenic differentiation and biomineralization capabilities of CSHA on hDPSCs with significant VEGF and DSPP gene upregulations were demonstrated.
Source link: https://europepmc.org/article/MED/36565040
Both fluorinated dual-crosslinked carboxymethyl chitosan nano-prodrugs with precise structure were swiftly produced by CMCS' reaction with water-soluble stimuli-responsive small molecule prodrug, glutaraldehyde, and heptafluorobutyric anhydride successively, addressing these challenges. The nano-prodrugs were able to display physicochemical stability at physiological pH, selective drug release, and synergistic cytotoxicity at tumoral intracellular pH/GSH, and beyond, circumventing the problem of dose-dependent toxicity and immunogenicity caused by those crosslinked or grafted via a single drug. Hence, the specific fluorinated dual-crosslinked CMCS-based nano-prodrugs have a great potential for selective clinical cancer treatment.
Source link: https://europepmc.org/article/MED/36549609
Deformed cancellous bone from the cortical bone fixation process is the source of a cavity in the bone, which results in abnormal bone healing. In this report, we developed bone marrow-laden and bone morphogenetic protein-2-laden clearly cured carboxymethyl chitosan hydrogels for cortical and cancellous bone healing. The 5 w/v% hydrogel exhibited a controlled BMP-2 release for 14 days, while the 7 and 10 w/v% hydrogels had a controlled BMP-2 release for 28 days.
Source link: https://europepmc.org/article/MED/36549614
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