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Hydroxyapatite and tricalcium phosphate account for 60% of the bone's content, and their combination has a greater effect on bone tissue engineering than either single component. The following HCP/CMC/gelatin scaffolds were constructed with different HCP components: group A, group B, and group C. In addition, the pore size of groups A and B was more homogeneous than that of group C. There were no significant differences in physicochemical characteristics among the three groups. The phase profiles of HA and u03b2-TCP did not change in the nanocomposite, according to the XRD results. However, cell adhesion and growth in group B were better than those in group A and group C, therefore, freeze drying combined with a stir foaming process may have a very high component limit. Group B had the best bone scaffold materials with the best characteristics for bone scaffold materials.
Source link: https://doi.org/10.3389/fchem.2022.958420
The nanocomposite contains AgNPs in a 5u201320 nm size, according to a scanning electron microscope. Inductively coupled plasma optical emission spectrometry (i. e. ) determined the silver content in the functionalized fabric, resulting in an average concentration of 13. 5 mg of silver per kg of functionalized fabric. On the surface of the functionalized cotton fabric fibers, SEM showed that silver nanoparticles had a uniform distribution. The functional fabric's physical and mechanical tests of tensile strength and color index revealed that it was no different than the control fabric. Our findings show that we have developed a new functionalized cotton fabric using green chemistry that does not change intrinsic characteristics of the fabric and has the ability to be used in the manufacture of hospital clothing.
Source link: https://doi.org/10.3390/pr10061207
The FCMCS-PDA-PAM hydrogels have a high swelling ratio, biodegradable materials, excellent mechanical properties, and a highly interconnected porous structure with PDA microfibrils, making them an ideal swelling ratio, biodegradable, excellent mechanical stability, excellent mechanical stability, and a tight interconnected porous structure with PDA microfibrils. Interestingly, the PDA microfibrils were created along with FCMCS fibers in the hydrogel networks, which has a major effect on hydrogels' biological stability. Using a minimum adhesion strength of the hydrogel to porcine skin was obtained at 29. 6 kPa. Hence, the adhesive hydrogel with multifunctionality has a great potential as a wound dressing material for infected wounds.
Source link: https://doi.org/10.3390/pharmaceutics14051028
However, the cumulative drug release rate of the samples containing 20 mM and 10 mM GSH medium was 79% and 68%, respectively, in pH 5. 0 at 20 h. This indicated that this nano-sized device is highly sensitive to GSH. In cancer cells, the inhibition ratio of folate-modified nanoparticles was higher than that of unmodified nanoparticles, but in normal cells, the cytotoxicity was lower. Moreover, in vitro cancer cell incubation studies, folate-modified nanoparticles therapeutics were significantly more effective than unmodified nanoparticles therapeutics. Our findings show that folate receptor stimulation and GSH stimulation can both significantly raise tumour intracellular drug release.
Source link: https://doi.org/10.3390/md16110439
In the presence of glutaraldehyde, a cross-linker, Carboxymethyl chitosan was synthesized and blended with gelatin to produce hydrogel microspheres by w/o emulsion cross-linking. In acidic and alkaline buffer media, 5-Fluorouracil was encapsulated to investigate its controlled release characteristics. The carboxymethylation of CS and the chemical stability of 5-FU in the formulations were confirmed by a Fourier transform infrared spectroscopy. In order to learn the water uptake properties, Equilibrium microsphere swelling was carried out in water. 5-FU in vitro was extended to 12 h in pH 7. 4 phosphate buffer, resulting in a 72 percent encapsulation rate.
Source link: https://doi.org/10.3390/pharmaceutics9020013
In vitro, this paper discusses our findings on the development of a unique self-cross-linkable hydrogel made up of oxidized alginate and carboxymethyl chitosan's synthesis as a cell carrier for dental enamel regeneration in vitro. The results revealed that among the three hydrogels tested, the one with the highest oxidized alginate gelation time and lowest swelling capacity had the fastest gelation time and the lowest swelling ability, and that all hydrogels were made with porous structures and could be delivered without clogging, with high porosity and was able to be introduced through a 20-gauge needle without clogging. Streptococcus mutans and Streptococcus sobrinus were also shown antibacterial activity against two pathogenic bacteria. HAT-7, a dental epithelial cell line, was tested for in vitro enamel regeneration, resulting in a high cell viability in the hydrogels during injection. This research has found that the oxidized alginate-carboxymethyl chitosan hydrogels could be used as an injectable cell carrier for dental enamel tissue engineering applications.
Source link: https://doi.org/10.3390/jfb13020071
Cotton is the most commonly used natural fiber for textiles; however, cotton fibers' ability to absorb large amounts of water, retain oxygen, and have a narrow surface area makes them more susceptible to microbial contamination, making them more suitable substrate for bacteria and fungi propagation. Using the well diffusion technique, the current study aims to continue the investigation of our manufactured nanocomposite and determine the antibacterial and antifungal activity of the nanocomposite against Escherichia coli, Staphylococcus aureus, and Candida albicans. The qualitative method of inhibition zone and the quantitative method of colony counting were both used to determine the antibacterial activity against E. coli and S. aury. The functionalized fabric was antibacterial free against E. coli and S. auus, as well as strong antifungal activity against C. albicans and A. n. . . . .
Source link: https://doi.org/10.3390/pr10061088
Calcium alginate fiber dressings have high absorption and unique gel forming results, but wound healing is limited due to the low bioactivity. Minocycline / CM-Chit solution was applied on the surface of plasma treated CAF needle-punched nonwovens, and then Mino loaded CM-Chit gel/CAF nonwovens composite dressings were created by EDC/NHS crosslinking, resulting in minocycline /CM-Chit solution in this report. Mino's burst release was halted by the tight structure of the CM-Chit gel, ensuring that the dressings had antibacterial activity in a limited period of release time. The prepared composite dressings were designed as new functional dressings, and they had a long history of wound healing.
Source link: https://doi.org/10.3390/md17100575
Intranasal delivery of therapeutic agents exploiting the olfactory or trigeminal connections nose-brain is a widely investigated way to cross the blood brain barrier. Although several bio-nanomaterials have been tested for encapsulation of neurotransmitter dopamine or dopaminergic drugs in order to recover the DA content in parkinsonian patients, the therapeutic agent's premature leakage restricts this approach. N, O, Carboxymethylchitosan-DA amide conjugate nanoparticles were prepared by the nanoprecipitation method and characterized by Olfactory Ensheating Cells' cytotoxicity, and uptake. The presence of amide linkages on the NPs surface was shown by high chemical stability of N, O-CMCS-DA NPs, and X-ray photoelectron spectroscopy data. The presence of mucin in the MTT test demonstrated their cytocompatibility with OECs, according to OECs, while cytofluorimetry and fluorescent microscopy revealed the internalization of labelled N, O -CMCS-DA NPs by OECs, which was boosted by the presence of mucin.
Source link: https://doi.org/10.3390/pharmaceutics14010147
To prepare Alg-CMCs dual polyelectrolyte microcapsules as a pH-sensitive carrier for efficient encapsulation and release of diclofenac sodium sodium, a simple ionic gelation process was used. The findings showed that two PECs protected Alg microcapsules from rapid disintegration at colony's origins and substantially reduced their porosity. In addition, the dual PECs microcapsules can safely encapsulate 95. 4% of DS-drug compared to 86. 3 and 68. 6% for Alg and Alg-CMCs microcapsules, respectively. In simulated colonic fluid [SCF; pH 7. 4] compared to those obtained in simulated gastric fluid [SGF; pH 1. 2], higher DS-release values were obtained in simulated colonic fluid [SCF; pH 7. 4] compared to those obtained in simulated gastric fluid [SGF; pH 1. 2].
Source link: https://doi.org/10.3390/pharmaceutics13030338
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