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The aim of the investigation was to compare the biopolymer CMCS hydrogels' performance and action with commercial ones, as well as select the best compositions for future research into wound-dressing applications. The tested hydrogels' modulus was higher than those that were control samples. The analyzed hydrogels were not cytotoxic, according to the test results, and in certain concentrations, they caused a modest rise in the number of cells compared to the control. The biocompatibility studies conducted on laboratory rats showed no adverse effect of hydrogels on animal tissues, confirming their biocompatibility and indicating that CMCS hydrogels could be used as wound-healing dressings in the future. Ionizing radiation has been shown to be a safe instrument for CMCS hydrogel synthesis and could be used in wound-healing therapy because it can also sterilize the product.
Source link: https://doi.org/10.3390/polym15010144
This research was designed to develop a pH-responsive nanocrystalline hydrogel drug delivery system for topical delivery of insoluble drugs based on carboxymethyl chitosan and oxidized hyaluronic acid's self-assembly behavior. The sodium periodate oxidation method was used to prepare OHA, and the concentration of CMC and OHA was adjusted using gel formation time as an indicator. The optimized prescription and process were shown to produce tanshinone extract nanocrystals with a particle size of nm and a polydispersity index of 0. 2173 -u00b1 0. 0008. CMC-OHA/TNCs could also release the drug continuously at the acne lesions, according to the acne lesions's in vitro, transdermal test findings. The minimum inhibitory concentration and minimum bactericidal concentration against Propionibacterium acnes and Staphylococcus aureus were considerably lower, and the diameter of the inhibition circle was obviously larger than that of TNCs and tanshinone extract crude suspensions.
Source link: https://doi.org/10.3390/ph15121534
Chitosan has been used as a nerve guidance conduit material for bridging peripheral nerve defects due to its biocompatible, biodegradable, and non-toxic characteristics. A composite, bioactive chitosan wire conduit conduit, herein, consists of an outer warp-knitted tube scaffold made from medical-grade chitosan fabric and an inner porous cross-linked carboxymethyl chitosan sponge with radial texture. With the composite bioactive chitosan-based nerve conduit, the nerve conduit was able to properly promote axonal regeneration and functional recovery after a ten-mm defect in rat sciatic nerve conduit was repaired.
Source link: https://doi.org/10.3390/molecules27249039
The ability of chitosan and carboxymethyl chitosan cryogels cross-linked with diglycidyl ether of 1,4-butandiol and poly has been tested in terms of 3D cultured HEK-293T cell line and preventing the scaffolds from fading with bacteria. The first attempts to use cryogels for 3D co-culturing of bacteria and human cells has been aimed at the creation of new models of host-u2013pathogen interactions and bioimplant-associated infections. The development of Staphylococcus biofilm in DMEM media was limited to modest antimicrobial activity against Pseudomonas fluorescence, and could not prevent the formation of Staphylococcus biofilm in DMEM media. Both P. fluorescence and S. aureus on the surface were more effective at preventing adhesion and colonization of both P. fluorescence and S. aureus species on the skin, rather than the ability to kill bacteria. Human cells were more susceptible to bacterial toxins in the 3D co-culture HEK-293T spheroids with P. fluorescence than in the 2D co-culture.
Source link: https://doi.org/10.3390/ijms232012276
Magnesium phosphate bone cement has exceptional degradable properties and demonstrates promising biocompatibility, and there is a continuing demand for artificial bone substitutes for bone repair and reconstruction. By utilizing a polymeric carboxymethyl chitosan-sodium alginate gel network, we functionally modified MPC. The new composites with 2% CMCS/SA had the most optimum physical and chemical characteristics, including mechanical stability, wash-out resistance, measurement time, injectable time, and heat release. The combination, both physically and biologically, promoted osteoblast cell attachment and proliferation. According to molecular mechanisms, new bone cement promoted the Wnt pathway by inhibiting the phosphorylation of u03b2-catenin, which is dependent on focal adhesion kinase. In a rat calvarial defect model, bone regeneration in the MPC-CMCS/SA scaffolds was shown by micro-computed tomography and histological investigation, as opposed to MPC alone. Overall, our report found that the novel composite had the ability to help correct common bone defects in clinical practice.
Source link: https://doi.org/10.1016/j.bioactmat.2022.06.017
Hydroxyapatite and tricalcium phosphate account for 60% of the bone's content, and their combination has a greater effect on bone tissue engineering than either single component. HCP/CMC/gelatin scaffolds were produced with different HCP components: group A, group B, and group C. Moreover, the pore size of groups A and B was more homogeneous than that of group C. There were no significant differences in physicochemical characterization among the three groups. The XRD findings revealed that the phase structures of HA and u03b2-TCP did not change in the nanocomposite. However, cell adhesion and growth in group B were better than those in group A and group C, so freezing drying in conjunction with a stir foaming process may have a high component limit. Group B had the highest bone scaffold material characteristics, according to Group B.
Source link: https://doi.org/10.3389/fchem.2022.958420
Cotton is the most commonly used natural fiber for textiles; however, cotton fibers' ability to absorb large amounts of water, retain oxygen, and have a large surface area make them more susceptible to microbial contamination, making them more suitable substrate for bacteria and fungi growth. The current research seeks to continue the testing of our newly developed nanocomposite and determine the antibacterial and antifungal activity of the nanocomposite based on silver nanoparticles and carboxymethyl chitosan against Escherichia coli, Staphylococcus aureus, and Candida albicans, which were based on the well diffusion method. The quantitative method of colony counting and the qualitative method of colony counting were both evaluated against E. coli and S. aureus.
Source link: https://doi.org/10.3390/pr10061088
Calcium alginate fiber dressings have outstanding absorption and unique gel forming results, but wound healing is limited due to the poor bioactivity. Minocycline /CM-Chit solution was coated on the surface of plasma treated CAF needle-punched nonwovens, and then Mino-loaded CM-Chit gel/CAF nonwovens composite dressings were produced by EDC/NHS crosslinking. The addition of Mino to Escherichia coli and Staphylococcus aureus's wound dressings demonstrated a significant increase in the wound dressings' antibacterial activity. The dressings were shown to have high cell biocompatibility by cell culture assay, according to a cell culture assay.
Source link: https://doi.org/10.3390/md17100575
Carboxymethyl chitosan, a chitosan of high molecular weight, was synthesized for improved water solubility. By 89%, the water solubility of high-molecular weight carboxymethyl chitosan was higher than that of native chitosan. H-CMCH's use in improving the moisturizer in mangosteen extract deodorant cream was investigated. Using a Corneometer 00ae, the various degrees of skin moisturizing on pig skin after using H-CMCH solution, compared to untreated skin, water, and propylene glycol for 15 and 30 min were investigated. After applying the treatment on pig skin for 30 min, the results revealed that the 0. 5% H-CMCH provided the best DM. The mangosteen extract was found to work with H-CMCH, a potent skin moisturizing agent, deodorizing activity on trans-2-nonenal odor, antioxidant properties, and antibacterial characteristics, according to the researchers.
Source link: https://doi.org/10.3390/polym14010178
However, the cumulative drug release rate of the samples containing 20 mM and 10 mM GSH medium reached 78. 9% and 60. 8 percent, respectively, in pH 5. 0 at 20 h. In cancer cells, the inhibition ratio of folate-modified nanoparticles was higher, compared to unmodified nanoparticles, but in normal cells, the risk of cytotoxicity was lower. Further, in vitro cancer cell incubation studies, folate-modified nanoparticles therapeutics were more effective than unmodified nanoparticles therapeutics.
Source link: https://doi.org/10.3390/md16110439
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