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Carboxylic Acid - Europe PMC

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Last Updated: 10 September 2022

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Mild and Chemoselective Carboxylic Acid Reduction Promoted by Borane Catalysis.

Although significant strides have been made in the development of chemoselective transformations of ubiquitous carboxylic acid groups, several obstacles remain. This reaction is demonstrated by a series of experimental and computational mechanistic experiments, with small amounts of in situ generated BH 3 playing a key role in the exquisite selectivity that is observed.

Source link: https://europepmc.org/article/MED/36047716


Radiation Chemical Yields of 7-Hydroxy-Coumarin-3-Carboxylic Acid for Proton- and Carbon-Ion Beams at Ultra-High Dose Rates: Potential Roles in FLASH Effects.

The resulting G value, which is the G value at each dose rate normalized by that at the normal dose, is almost identical to 27. 5 and 55 MeV proton beams, according to the relative G value. In addition, we investigate the contribution of oxygen to the production of 7OH-C3CA. The oxygen reduction in the decrease of 7OH-C3CA yields may be directly related to that of decrease in the G value of 7OH-C3CA. However, the decrease rate of G value under UHDR is much higher than the oxygen consumption. This finding showed that the presence of water radiolysis species grown by neighborhood track's interactions could be significantly related to UHDR's effects.

Source link: https://europepmc.org/article/MED/35738014


Establishment of an HPLC Method for Determination of Coumarin-3-Carboxylic Acid Analogues in Rat Plasma and a Preliminary Study on Their Pharmacokinetics.

In rat plasma analysis and a preliminary report on pharmacokinetics, a simple high-performance liquid chromatography system was developed and validated for the determination of coumarin-3-carboxylic acid analogues and a preliminary study on pharmacokinetics. The correlation coefficient in the C3A linear equation is equal to 0. 9990 in terms of the 0. 9990 correlation coefficient. After 60% ethanol extraction by gavage, the new high-performance liquid chromatography-photo diode array detector system developed in this study can be used to distinguish and determine the content of C3AA in plasma of rats. To some degree, the plasma concentration-time curve and pharmacokinetic data show the absorption of C3AA in rat blood following oral administration.

Source link: https://europepmc.org/article/MED/34491317


5-Amino-3-methyl-Isoxazole-4-carboxylic Acid as a Novel Unnatural Amino Acid in the Solid Phase Synthesis of α/β-Mixed Peptides.

As a result, the creation of new unnatural amino acids and the methods of incorporation of them into the peptide chain is a significant task. We've shared here an excerpt from our investigation into the possibility of 5-amino-3-methyl-isoxazole-4-carboxylic acid use in the solid phase peptide synthesis. The obtained results indicate the possibility of using this b03b2-amino acid in the creation of a new class of bioactive peptides.

Source link: https://europepmc.org/article/MED/36080386


Overexpression of acdS gene encoding 1-aminocyclopropane-1-carboxylic acid deaminase enzyme in petunia negatively affects seed germination.

The seeds' overexpression of acds in petunia negatively impacts seed germination by reducing ethylene biosynthesis and signaling genes and the introduction of abscisic acid biosynthesis genes in the seeds. In this research, acdS overexpression significantly reduced seed weight and germination rate in transgenic petunia cv. Merage Rose relative to wild type by the suppression of ethylene biosynthesis and signaling genes and the synthesis of abscisic acid biosynthesis genes. The addition of exogenous ACC and gibberellic acid to the germination medium increased the germination rate of T5 seeds and GA 3 in T5 seeds and GA 3 increased the germination rate of T12 seeds and GA 3. In this research, we found a negative role of acds in seed germination in petunia. To improve tolerance to abiotic stress, we recommend considering the negative effects of acdS on seed germination when overexpressing the gene in horticultural crops.

Source link: https://europepmc.org/article/MED/35988098

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions