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Carboplatin Trial - Wiley Online Library

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Last Updated: 03 June 2022

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Exposure‐Response Model With Time‐Varying Predictors to Estimate the Effects of Veliparib in Combination With Carboplatin/Paclitaxel and as Monotherapy: Veliparib Phase 3 Study in BRCA‐Mutated Advanced Breast Cancer (BROCADE3) Trial

PFS risk analyses were performed using Kaplanu2010Meier charts and cox proportional hazards models using diagnosis alone or as time-u2010 dependent predictors to determine the effect of veliparib in combination with carboplatin/paclitaxel and monotherapy as time-u2010 dependent predictors. A modest, non-scientific benefit of adding veliparib to carboplatin/paclitaxel is shown by a significantly larger benefit of adding veliparib to the carboplatin/paclitaxel. When veliparib was administered in combination with carboplatin/paclitaxel or monotherapy, a flat correlation was revealed as an additional time-varying predictor in the cox proportional hazards model. If carboplatin/paclitaxel were discontinued before disease progression in this patient population, these results support the dose regimen of veliparib in combination with carboplatin/paclitaxel and continuation of veliparib as monotherapy.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jcph.2061

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions