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BackgroundSquamous carcinoma of the anal canal is a human papillomavirus-driven disease with poor prognosis in locally advanced or recurrent settings. Retinmilab's POD1UM-202 demonstrated robust clinical activity and an anticipated safety profile in patients with advanced SCAC who were undergoing platinum-based chemotherapy. The addition of retifranl to the existing care carboplatin-u2013paclitaxel in patients with inoperable locally recurrent or metastatic SCAC not previously treated with systemic chemotherapy will be included and stratified by PD-L1 expression, region, and severity of disease, according to POD13516. Patients will be given up to six induction cycles of carboplatin and paclitaxel every 28 days by SOC.
Source link: https://doi.org/10.3389/fonc.2022.935383
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