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CA IX inhibition has been shown to reduce cancer cell proliferation and metastasis by pHe/pHi modulation and the improvement of ferroptosis among other things by a multitude of studies. Numerous studies have shown that cytotoxic drugs combined with CA inhibitors in various cancer types. We investigated the inhibitory effect of boric acid, an inorganic Lewis acid, on CA IX as well as other isoforms.
Source link: https://europepmc.org/article/MED/35535546
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