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Carbon Nanotubes - U.S. Department of Veterans Affairs

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Last Updated: 02 November 2021

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Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity.

Because dispersion of the SWCNTs increases their aspect ratio relative to as-produced accumulations, we directly check the dominating hypothesis that lung toxicity connected with SWCNTs contrasted with various other carbon frameworks is attributable to the large aspect ratio of the private bits. Thirty days after their intratracheal administration to mice, the granuloma-like frameworks with moderate fibrosis in the huge respiratory tracts observed in mice treated with aggregated SWCNTs were missing in mice treated with nanoscale distributed SWCNTs. Examination of lung sections from mice treated with nanoscale distributed SWCNTs disclosed uptake of the SWCNTs by macrophages and progressive clearance with time.

Source link: https://doi.org/10.1021/nl9042483

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