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Abstract Background Intrinsically fluorescent glucose derived carbon nanospheres are able to penetrate mammalian cells and cross the blood brain barrier. We show that CSP penetration into the mammalian cells is an ATP-dependent clathrin-mediated endocytosis process by using confocal photography. Conclusion The endocytosis of Glucose-derived CSP into mammalian cells is an ATP dependent process mediated by clathrin coated pits. CSPs use the surface functional groups to target cells containing glucose transporters on its membrane, thereby engendering the possibility of a targeted attack of the brain or cancer cells.
Source link: https://doi.org/10.1186/1477-3155-10-35
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