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There is no such and effective treatment in clinic for brain injury caused by carbon monoxide poisoning, and there is no definitive and safe way to recover brain injury caused by carbon monoxide poisoning. We screened Salvia Miltiorrhiza's acute COP brain injury by a network pharmacology, and established the pharmacological mechanism of multicomponent, multitarget, and multisignal pathway in Salvia Miltiorrhiza by network pharmacology in this research. A total of 216 male healthy Sprague Dawley rats were randomly assigned to a normal control group, a COP group, and a Tanshinone IIA sulfonate treatment group in order to better understand the clinical role of Salvia Miltiorrhiza on acute brain injury based on the findings of network analysis. The primary inhalation in a hyperbaric oxygen chamber established acute severe COP in a rat model.
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