Carbon-13 Magnetic Resonance - Europe PMC

Monitoring Early Glycolytic Flux Alterations Following Radiotherapy in Cancer and Immune Cells: Hyperpolarized Carbon-13 Magnetic Resonance Imaging Study.

To record the very early glycolytic alterations in the irradiated cancer and immune cells, we made an initial DNP 13 C-MRI research by using hyperpolarized [1- 13 C] pyruvate to study human FaDu squamous carcinoma cells, HMC3 microglial cells, and THP-1 monocytes prior to and after irradiation. Adhering to irradiation, the pyruvate-to-lactate conversion rates on DNP 13 C-MRI were significantly reduced in the FaDu and the HMC3 cells but enhanced in the THP-1 cells. Finally, DNP 13 C-MRI non-invasively recorded the different glycolytic modifications among cancer and immune systems in response to irradiation, indicating its capacity for professional use in the future.

Source link: https://europepmc.org/article/MED/34436459

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions