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To record the very early glycolytic alterations in the irradiated cancer and immune cells, we made an initial DNP 13 C-MRI research by using hyperpolarized [1- 13 C] pyruvate to study human FaDu squamous carcinoma cells, HMC3 microglial cells, and THP-1 monocytes prior to and after irradiation. Adhering to irradiation, the pyruvate-to-lactate conversion rates on DNP 13 C-MRI were significantly reduced in the FaDu and the HMC3 cells but enhanced in the THP-1 cells. Finally, DNP 13 C-MRI non-invasively recorded the different glycolytic modifications among cancer and immune systems in response to irradiation, indicating its capacity for professional use in the future.
Source link: https://europepmc.org/article/MED/34436459
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