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The present study utilized data from participants randomized to the 'choice' arm of a trial examining whether having the ability to pick a diet regimen yields greater weight loss than being arbitrarily assigned to a diet. At research entry, individuals went to a group session throughout which they were provided tailored comments showing which diet was most consistent with their food choices using the Geiselman Food Preference Questionnaire, details about both diets, and instance dishes for every diet.
Source link: https://doi.org/10.1016/j.appet.2014.08.023
Liver steatosis in nonalcoholic fatty liver condition is influenced by genetics and diet. We uncovered that both C57BL/6J and DBA/2J mice developed excessive weight to a similar degree without the attribute of liver swelling after being fed an HFHC diet for 16 wk. C57BL/6J mice in the HFHC diet team displayed severe pan-lobular steatosis, a significant boost in hepatic triglyceride levels, and profound peripheral IR. On the other hand, DBA/2J mice in the HFHC diet team established just a mild degree of pericentrilobular hepatic steatosis that was connected with moderate changes in outer IR. Interestingly, both C57BL/6J and DBA/2J established serious hepatic IR after HFHC diet treatment. Collectively, these data recommend that the intensity of diet-induced hepatic steatosis is correlated to the degree of peripheral IR, not with the extent of weight problems and hepatic IR. Peripheral rather than hepatic IR is a dominant aspect of pathophysiology in nonalcoholic fatty liver illness.
Source link: https://doi.org/10.1152/ajpgi.00291.2013
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