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Insulin resistance plays a role in the pathogenesis of several conditions, including type 2 diabetes mellitus, cardiovascular disease, non-alcoholic fatty liver disease, obesity, and neurodegenerative disorders, including Alzheimer's disease, in the United States. The ketogenic diet, as an affordable treatment for seizure control, appeared in the 1920s as a low-carbohydrate/high-fat diet. Both physicians and researchers in a KD's investigation investigated the positive, influential strengths of the KD, its potential risks, various ways that might be used for it, and the challenges faced by both physicians and subjects throughout a KD. According to this SWOC study, the KD addresses the pathophysiological causes of IR-related diseases such as chronic inflammation, oxidative stress, and mitochondrial strain. In addition, it draws scientists and physicians' attention to the KD's promise and challenges before KD's introduction.
Source link: https://doi.org/10.3390/metabo12111126
The aim of this research was to investigate the effects of dietary carbohydrate restriction and aerobic exercise on Retinol Binding Protein 4 and Fatty Acid Binding Protein 5 in middle-aged men with metabolic syndrome. Among the 12-weeks intervention, body mass, body mass index, and body fat], insulin sensitivity, insulin sensitivity, and MetS parameters were evaluated before and after the 12-weeks intervention. As compared to a control group, and marginally reduced the Zmets as compared to the exercise group, but significantly reduced the body fat percentage, body mass index, Zmets, RBP4, and the homeostasis model of insulin resistance. When compared to the control group, KD significantly reduced RBP4 levels. Improved RBP4, HOMA-IR, as well as differences in middle-aged men with metabolic syndrome, as a result of combining carbohydrate restriction and AE alone, as well as different body composition and MetS factors.
Source link: https://doi.org/10.1017/s0007114522003580
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