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Carbohydrate Diet Fat - Europe PMC

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Last Updated: 05 August 2022

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Preoperative Short-term High-Carbohydrate Diet Provides More High-Quality Transplantable Fat and Improves the Outcome of Fat Grafts in Mice.

Background Patients with a low BMI may have insufficient high-quality adipose tissue for transplantation. Objectives: The authors investigated inguinal fat pad change in mice fed on a short-term high-fat diet or a high-carbohydrate diet preoperatively, as well as the morphological and histological differences after transplantation. Using quantitative polymerase chain reaction, the Vascular endothelial growth factor-u03b1 and platelet-derived growth factor-u03b1 expression were determined. Conclusions In the HFD and HCD groups, the inguinal fat pad volume increased. Adipocyte browning was observed in HCD-fed mice's inguinal fat, as well as the higher uncoupling protein-1 level. HCD grafts with improved volume retention and reduced oil cyst formation, perhaps due to improved angiogenesis and adipogenesis. HCD expanded adipose tissue and increased graft survival rates, which may be due to fat browning before grafting and enhanced angiogenesis after grafting.

Source link: https://europepmc.org/article/MED/35460566


Very Low-Carbohydrate High-Fat Diet Improves Risk Markers for Cardiometabolic Health More Than Exercise in Men and Women With Overfat Constitution: Secondary Analysis of a Randomized Controlled Clinical Trial.

Purpose This is a randomized controlled parallel group research investigated the effects of a low-carbohydrate rich diet and a high-intensity interval training program over 12-weeks on cardiometabolic risk factors in people with overfat constitutions. Methods Ninety-one participants out of 109 total completed the study. Plasma samples were obtained before and during the intervention and after 4 and 12 weeks. The homeostasis model assessment of insulin resistance, Adpn/Lep ratio, TG/HDL-C ratio, and TyG index were calculated and evaluated. Before the intervention, blood pressure was assessed before and after 4, 8, and 12 weeks. After 12 weeks, absolute changes in HOMA-IR, Adpn/Lep ratio, LDL-C, and diastolic blood pressure were divided by study groups. Results A 12-week VLCHF diet intervention in people with overfat constitution is successful in improved changes in the HOMA-IR, Adpn/Lep ratio, and diastolic blood pressure. There were no additional benefits for the measured variables except for the analyzed variables.

Source link: https://europepmc.org/article/MED/35677551


A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism-Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers.

Background and objectives Insights into the nature of gut changes after different diets have increased the possibility of how diet changes can be used to treat type 2 diabetes and obesity. Methods Five healthy individuals were randomly distributed in arbitrary order and a crossover study design, two weeks of iso-caloric high-fat diet and high-carbohydrate diet, according to Fifteen Healthy People. Following each dietary intake, jejunal mucosa samples were collected and tested for protein expression by immunofluorescence and western blotting. In vitro in Caco-2 and human jejunal enteroid monolayer cultures, the development of SGLT1 through histone acetylation was investigated by histone acetylation. HFD, in comparison to HCD, reduced jejunal Ussing chamber epithelial glucose transport and the expression of apical transporters for glucose and fructose, while the expression of the basolateral glucose transporter GLUT2 was increased. A ketogenesis-induced sirtuin activation was demonstrated in Caco-2 and human jejunal enteroid monolayer cultures, which also reduced SGLT1 expression, which reduced SGLT1.

Source link: https://europepmc.org/article/MED/35565929

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions