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Carbohydrate Metabolism - Europe PMC

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Last Updated: 02 January 2023

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Dysregulated carbohydrate and lipid metabolism and risk of atrial fibrillation in advanced old age.

Different aspects of metabolic regulation are represented in the fasting and postload measurements of glucose and non-esterified fatty acids. We attempted to investigate their individual contributions to AF risk simultaneously. Methods We analyzed fasting and postload glucose, as well as NEFA in the Cardiovascular Health Study to find links with AF incidence and, secondarily, with ECG parameters of AF risk that were not available at baseline. Both glucose measurements, but not NEFA, were positively connected with increased P wave terminal force in V1; the association remained significant only for postload glucose when the two measures were combined — but not NEFA. Relationships in women were found in exploratory studies, with significant interactions between sex and fasting NEFA and postload glucose relative to AF. The connection with the event AF was found among women but not among men. Conclusions Among older adults, postload glucose was positively correlated with event AF, with stable findings for PTFV1.

Source link: https://europepmc.org/article/MED/36549682


DNA methylation of pck1 might contribute to the programming effects of early high-carbohydrate diets feeding to the glucose metabolism across two generations in zebrafish (Danio rerio).

This research aims to investigate the mechanisms that explain those nutritional programming changes in zebrafish two generations by epigenetic modifications, as well as the effects of early high-carbohydrate stimulation on glucose metabolism in zebrafish over two generations. The larvae were given a high-carbohydrate diet from the first feeding to the end of the yolk sac and 5 days after yolk-sac exhaustion. In FF and YE, the glucose levels were lower in FF, and the mRNA levels of phosphoenolpyruvate carboxykinase 1 were reduced. In conclusion, these results revealed that an early high-carbohydrate stimulus could significantly reprogram glucose metabolism in adult zebrafish, that those changes could be partially passed on to the next generation, and that the pck1 DNA methylation might be a useful epigenetic marker to those processes.

Source link: https://europepmc.org/article/MED/36481836


Establishment and validation of a carbohydrate metabolism-related gene signature for prognostic model and immune response in acute myeloid leukemia.

Introduction The heterogeneity of treatment responses in acute myeloid leukemia patients poses major difficulties for risk scoring and treatment stratification. We investigated whether carbohydrate metabolism related genes could improve prognostic classification and predict immune responses and treatment in AML patients using this multicohort study. Patients were divided into a high-risk group and a low-risk group according to the median risk score. We investigated the CRG's predictability of AML survival using TCGA and GEO public data cohorts and our cohort. The immune microenvironment in this high-risk group was significantly reduced, according to an analysis of tumor-infiltrating immune cells. Discussion of the CRG signature was instrumental in immune response to AML. Prognostic classifications in AML are shown in our report, which may include new insights into the development of precise targeted cancer therapies.

Source link: https://europepmc.org/article/MED/36544784

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions