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Carbohydrate Lipid - U.S. Department of Veterans Affairs

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Last Updated: 02 February 2022

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Towards Understanding the Direct and Indirect Actions of Growth Hormone in Controlling Hepatocyte Carbohydrate and Lipid Metabolism.

The GH controls modulate the production and operation of insulin-like growth factor 1 and insulin via its GH receptor, allowing it to influence the production and function of insulin-like growth factor 1 and insulin. The role of GH in metabolic health and disease are discussed in caveats and challenges relating to the model systems used and areas that warrant further investigation to gain a more comprehensive picture of the role GH plays in metabolic health and disease.

Source link: https://doi.org/10.3390/cells10102532


Hepatocyte-Specific Hepatocyte Nuclear Factor 4 Alpha (HNF4) Deletion Decreases Resting Energy Expenditure by Disrupting Lipid and Carbohydrate Homeostasis.

Hepatocyte differentiation and control of genes involved in lipid and carbohydrate metabolism, including those that control VLDL secretion and gluconeogenesis, is required for Hepatocyte differentiation and regulation of gene expression. Hepatocyte nuclear factor 4 alpha is required for hepatocyte differentiation and regulation of gene expression in lipid and carbohydrate metabolism. We used indirect calorimetry to determine the effect of hepatocyte-specific HNF4 deletion in mice on whole-body energy expenditure and substrate utilization in fed, fasted, and high-fat diet conditions in this research. Despite no change in energy intake or evidence of positive energy balance, HNF4-KO mice demonstrated reduced body mass due to fat mass depletion. HNF4-KO livers show reduced gluconeogenesis, reduced VLDL export and hepatic oxidation in all feeding conditions, according to previous reports. During fed and fasted conditions, our results show that deletion of hepatic HNF4 contributes to increased energy intake, dietary carbohydrates, and intestinal lipid absorption, which resulted in reduced whole-body energy expenditure.

Source link: https://doi.org/10.3727/105221621X16153933463538

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions