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Irrritable bowel syndrome is a common medical disorder for which diet intervention can be a helpful therapy. Mast cells can be stimulated by AGEs and play a role in IBS. We've treated mice with lactose or fructosaccharides, with or without co-administration of pyridoxamine, and examined the colonic mucus barrier. We have discovered that an elevated intake of lactose and fructosaccharides causes a dysregulation of the colonic mucus barrier, increasing mucus discharge in the empty colon, while decreasing consistency and decreasing average thickness of the fecal pellet. Changes were correlated with increased mast cell counts, indicating a role in the crosstalk between these and goblet cells. According to this review, excess intake of fermentable carbohydrates can lead to colonic mucus barrier dysregulation in mice, which can be exacerbated by increased mucosal cell counts and increased mucosal mast cell counts.
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