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Carbohydrate Fat Rats - Europe PMC

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Last Updated: 02 November 2021

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Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats.

The present research study elucidates the safety effects of sesamol versus NASH and atherosclerosis in HF-HCC diet-fed rats. At the end of the experiment, sesamol supplementation reduced HF-HCC diet-induced body weight gain and raised absolute liver and fat weights in rats. Histological examinations showed that dietary sesamol not only alleviated hepatic balloon deterioration, fibrosis, swelling and steatosis, but mitigated lipid buildup and coarse elements in the aorta arch in HF-HCC diet-fed rats. Furthermore, sesamol treatment reduced uric acid degrees both in product and the liver by its effect on the inhibition of xanthine oxidase task and/or its expression, which may be carefully associated with the restraints of NLRP3 expression and ERS-IRE1 signaling path activation in HF-HCC diet-fed rats. These searchings for showed that sesamol minimized NASH and atherosclerosis in HF-HCC diet-fed rats, and might be a powerful dietary supplement for security versus these diseases.

Source link: https://europepmc.org/article/MED/34606548


Hepatic Energy Metabolism Underlying Differential Lipidomic Responses to High-Carbohydrate and High-Fat Diets in Male Wistar Rats.

Purpose We aimed to elucidate mechanisms whereby dietary carbohydrate and fat differentially impact hepatic and distributing TG, and exactly how these mechanisms associate with fatty acid composition. Techniques Six-week-old, ∼ 300 g man Wistar rats were fed a high-carbohydrate, low-fat [HC; 61. 3% of energy carbohydrate] or a low-carbohydrate, high-fat diet regimen for 4 wk. Outcomes In HC-fed rats, plasma TG was dual and hepatic TG 27% of that in HF-fed rats. Verdicts In male Wistar rats, nutritional carbohydrate was exchanged specific fatty acids using hepatic lipogenesis, adding to greater plasma TG and total fats contrasted with high-fat feeding. In comparison, the high-fat, low-carbohydrate feeding enhanced hepatic fat content, without impacting hepatic mitochondrial fatty acid oxidation.

Source link: https://europepmc.org/article/MED/34132338


High carbohydrate high fat diet causes arterial hypertension and histological changes in the aortic wall in aged rats: The involvement of connective tissue growth factors and fibronectin.

Approaches A research was executed in male Wistar rats, which were separated into the adhering to groups: 1st - ignorant young rats; 2nd - young rats, revealed to HCHFD; 3rd - ignorant old rats; 4th - old rats subjected to HCHFD. The age of old rats was 540 days, and young rats 150 days at the end of the diet plan. Results The intensity of arterial hypertension and its histological indications in the aortic wall was located to be most obvious in elderly rats went on a HCHFD. An increase in the serum concentration of fibronectin was connected with raised endothelin-1, ctgf and tgfβ serum degrees.

Source link: https://europepmc.org/article/MED/34455071

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions