Carbohydrate Diet Type 2 Diabetes - Europe PMC

SGLT2 inhibitor versus carbohydrate-restricted isocaloric diet: Reprogramming oxidation in type 2 diabetes

Methods: 23 patients with type 2 diabetes treated with titrated basal-bolus insulin subsequent to the control diet alone, administration of canagliflozin 100 mg/day to the CON, or CRIC diet for 12 weeks were enrolled in this randomized 3-arm open-label prospective research. Despite the fact that the fasting EE in all groups was similar, postprandial EE was much higher in the SGLT2i and CRIC groups in comparison to the CON group. In the SGLT2i and CRIC groups, the fasting RQ was lower, while delta-RQ was increased due to increased carbohydrate substrate utilization in the SGLT2i and CRIC groups in comparison to the CON group. In the CRIC group, the total recommended daily dose of insulin was noticeably higher, although the amount of available carbohydrate was also present in the CRIC and SGLT2i groups. A CRIC diet's higher insulin intake indicates that a relatively high lipid and protein ratio could influence insulin requirements.

Source link: https://europepmc.org/article/PPR/PPR498255

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