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Carbohydrate - Europe PMC

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Last Updated: 10 September 2022

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Insights into the correlations between prebiotics and carbohydrate metabolism in fish: Administration of xylooligosaccharides in Megalobrama amblycephala offered a carbohydrate-enriched diet

This research looked at the effects of XOS on the growth results and glycolipid metabolism of blunt snout bream fed a high carbohydrate diet. Fish were fed a control diet, a HC diet, and a HC diet supplemented with 0. 55, 1. 0%, 1. 55, and 2. 0% XOS respectively for 12 weeks. u03b2-oxidation, glycolysis, glycogenesis, the pentose phosphate pathway, and fatty acid biosynthesis can be improved by up-regulating glucose transport, glycolysis, cellular metabolism, blunt snout's ketchamine pathway and fatty acids by up-regulating gluconeogenesis and fatty acid biosynthesis, but not down-regulating gluconeogenesis and fatty acid biosynthesis.

Source link: https://europepmc.org/article/MED/IND607873336


Short initial period of high carbohydrate feeding improves nutrient utilisation in juvenile Nile tilapia (Oreochromis niloticus) fed a high carbohydrate diet

The purpose of this research was to investigate the effects of different timings of early carbohydrate feeding stimulus on Nile tilapia's growth rate and CHO metabolism later in life. In weeks 2121-201324, juvenile fish were tested for the presence of CHO metabolic programming, and juvenile fish were conditioned with a high-CHO diet. Early HC/LP stimulation improved juvenile growth prospects, according to our findings, suggesting that a history of early HC/LP stimulation aids in the growth of juveniles. Moreover, this report shows that a 1-week early HC/LP feeding period could be sufficient to prepare juvenile tilapia for improved nutritional use due to longer lasting negative effects on growth results than short-HC/LP therapy.

Source link: https://europepmc.org/article/MED/IND607859719


Weight loss via a low-carbohydrate diet improved the intestinal permeability marker, zonulin, in prostate cancer patients.

We investigated the effect of LCD on an IP marker, zonulin, and an inflammation marker, a high-sensitivity C-reactive protein, in the Carbohydrate and Prostate 2 clinical study, which showed that a low-carbohydrate diet reduced weight in men with PC and potentially slowed PC disease progression. Weight loss was strongly associated with log loss, so log change was notably linked to weight loss, the longer the PSADT lasted. However, the mediation report showed that zonulin was not a significant intermediary mechanism of PSADT's change in weight change. As shown by the PSA doubling time, intestinal permeability increases in prostate cancer risk, particularly by changing intestinal permeability.

Source link: https://europepmc.org/article/MED/35486445


Structural enrichment and identification of lignin-carbohydrate complex in alkaline stabilized system

Phenyl glycosidic bonds in LCC persist stably in an alkaline environment. The effects of enzyme use and treatment time on LCC enrichment were discussed in this study. The LC bond of LCC samples was dominated by the phenyl glucoside bond, according to the composition of lignin and structural integrity, satisfying the requirements of lignin enrichment and structural integrity could be achieved by this technique.

Source link: https://europepmc.org/article/MED/IND607833751


Phenotype-genotype analysis of Latilactobacills curvatus from different niches: Carbohydrate metabolism, antibiotic resistance, bacteriocin, phage fragments and linkages with CRISPR-Cas systems

Nine strains of L. curvatus were isolated from various sources, including feces and fermented vegetables, and compared to 25 strains from the NCBI database, allowing researchers to investigate the similarities in the genomes of the two species. The average genome size, GC content, and CDS of L. curvatus were 1. 94 MB, 41. 9%, and 1825, respectively, according to the researchers. L. curvatus' pan-genome was in a closed state. With a few IIC and IE varieties remaining, the CRISPR system of 34 strains of L. curvatus was mainly discovered to be of the IIA type with some IIC and IE varieties.

Source link: https://europepmc.org/article/MED/IND607826456


Hybrid metagenome assemblies link carbohydrate structure with function in the human gut microbiome.

However, the role of carbohydrate structure in influencing microbiota community selection and the succession of carbohydrate-degrading microbes is still unclear. Bacterial species isolated as carrying genes encoding starch binding modules increased in abundance in reaction to starches. The use of hybrid metagenomics has enabled the identification of several uncultured species with the ability to degrade starch substrates for future research.

Source link: https://europepmc.org/article/MED/36076058


Rapid Evolution of Glycan Recognition Receptors Reveals an Axis of Host-Microbe Conflicts at Carbohydrate-Protein Interfaces

Signatures of rapid evolution have been found in several host immunity proteins involved in the detection of pathogenic protein substrates, but whether the same signals can be found in host proteins involved in interactions with other pathogen-derived molecules has received less attention. We have evidence that several mammalian immune receptors involved in the detection of microbial glycans have been subjected to recurrent positive selection. At a site in the Melanin Lectin gene that has been attributed to an elevated risk of invasive fungal disease, we found convergent patterns of substitution in distinct primate populations. These results show that host-microbe conflicts extends far beyond the world of host-viral protein-protein interactions to the world of microbial glycans and fungi.

Source link: https://europepmc.org/article/PPR/PPR541348


Impact of maternal dietary carbohydrate intake and vitamin D-related genetic risk score on birth length: the Vitamin D Pregnant Mother (VDPM) cohort study.

Background Our aim was to investigate the relationship between maternal vitamin D status and IGF-1 levels in healthy Minangkabau pregnant women and their influence on newborn anthropometry results, as well as whether this relationship could be changed by dietary intake using a nutrient approach. Using linear regression analysis, the effect of the GRSs on IGF-1, vitamin D, and newborn anthropometry, as well as the relationship between the GRSs and dietary causes were determined. Pregnant mothers with elevated carbohydrate intake and who had a u22652 risk alleles of VDR-GRS gave birth to babies with dramatically shorter birth lengths than those born to mothers with 2 risk alleles.

Source link: https://europepmc.org/article/MED/36071390


Exploration of rumen microbial and carbohydrate-active enzyme profiles in cattle fed coir a lignin-rich diet using a metagenomic approach.

Coconut coir may be one of several popular feed supplements. A metagenomic investigation was conducted to determine the effects of various amounts of coconut coir as a feed supplement on cattle rumen microbiome. According to the amplicon study, the group of cattle raised without the coconut coir has a higher number of genera than cattle raised with mixed ration. Biological phyla Bacteroidetes were prevalent in the liquid fraction, followed by adhesives and Fibrobacteres, whereas Tenericutes, TM7, SRI, Verrucomicrobia, Lentisphaerae, and Elusimicrobia had decreased with the increase in the coir concentration. In both the treatments and the control, carbohydrate metabolism had high levels as compared to the placebo. The microbiome does change after feeding coir as a supplement, and can be used as a feed for cattle, according to the report.

Source link: https://europepmc.org/article/MED/36075329


Highly expressed carbohydrate sulfotransferase 11 correlates with unfavorable prognosis and immune evasion of hepatocellular carcinoma.

Here, we reported that carbohydrate sulfotransferase 11 was upregulated in HCC and related to a mature TNM stage. HCC patients with TP53 mutation had elevated CHST11 levels, according to the HCC patients with TP53 mutation, who had higher CHST11 expression. Cellular functional experiments showed that knocking down of CHST11 in HCC inhibited cell proliferation and metastasis. According to continuing immuno-related studies, CHST11 expression promoted Tregs recruitment in HCC and promoted the expression of checkpoints PD-L1/PD-1, which culminated in HCC's immune suppression. Targeting CHST11 can prevent Tregs infiltration and increase the antineoplastic activity of immune checkpoint inhibitors, giving a new insight into the combination immunotherapy with Treg-modulating agents and PD-1 inhibitors, giving a new insight into the combination immunotherapy using Treg-modulating agents and PD-L1/PD-1 inhibitors.

Source link: https://europepmc.org/article/MED/36062845

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions