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Carbohydrate - Astrophysics Data System

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Last Updated: 10 January 2023

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Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota

The variety of CAZymes in gut microbios is extensive, led by the human gut symbiont Bacteroides thetaiotaophthaloases, as well as 208 homologues of susC and susD-genes coding for two outer membrane proteins involved in starch utilization 1,4. Here we present the first porphyranas from a member of the marine Bacteroidetes Zobellia galactanivorans focusing on the sulphated polysaccharide porphyran of marine red algae of the genus Porphyra. Porphyranases and agarases are common in the Japanese population 6 and are absent in metagenome data 7 from North American individuals, according to our comparative gut metagenome results. These novel CAZymes were ingested in human gut bacteria by seaweeds, according to this information, and that contact with non-sterile foods may have been a common factor in CAZyme diversity in human gut microbes.

Source link: https://ui.adsabs.harvard.edu/abs/2010Natur.464..908H/abstract


Associations of overall and specific carbohydrate intake with anxiety status evolution in the prospective NutriNet-Santé population-based cohort

a baseline and once at follow-up; "Existent" = high anxiety at baseline and once at follow-up, with just high anxiety at baseline and a sequel. The % energy from carbohydrates, total carbohydrate, and complex carbohydrate intakes were all associated with elevated risks of "Persistent" anxiety, according to reports, while 100% fruit juice intake showed less risk of "Persistent" anxiety. This prospective report showed strong links between dietary carbohydrate intake and anxiety status change among French adults.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1221647K/abstract


Alteration of eggs biochemical composition and progeny survival by maternal high carbohydrate nutrition in a teleost fish

Dietary maternal lipids have been cited as a significant factor in reproductive outcomes. However, the effects of carbohydrates have been little investigated, though plant-derived carbohydrates may be more popular in broodstock diets. For an entire reproductive cycle, the 2-year-old female trout was fed either a control diet with no carbohydrate and a high protein content, or a plant-derived carbohydrate diet containing 32. 5% carbohydrate and 42. 9% protein for an entire reproductive cycle. Although the one-year HC diet did not influence female growth nor spawning quality, spawns quality, such diet has contributed to the variation of eggs size within spawns.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1216726C/abstract


Acoustic force spectroscopy reveals subtle differences in cellulose unbinding behavior of carbohydrate-binding modules

Cellulases are multimodular enzymes that catalyze cellulose hydrolysis into glucose. Particularly for heterogeneous reactions at solid-liquid interfaces, the subtle interplay between CBM binding and CD activity is poorly understood. We've developed a single-molecule force spectroscopy system to investigate CBM dissociation from cellulose to infer the molecular mechanism controlling substrate recognition and dissociation.

Source link: https://ui.adsabs.harvard.edu/abs/2022PNAS..11917467H/abstract


The Maize Pathogen Ustilago maydis Secretes Glycoside Hydrolases and Carbohydrate Oxidases Directed toward Components of the Fungal Cell Wall

Regardless of their lifestyle, filamentous fungi must repair their own cell wall to grow and proliferate. ABSTRACT explains: Filamentous fungi are keystone microorganisms in the regulation of several processes on Earth, such as plant biomass decay and pathogenesis, as well as symbiotic interactions. Two new Cazaymes, Um GH161-A and Um AA3_2-A, were both developed and biochemically characterized by We heterologously produced and biochemically described. Um 203_1-A depicts a dehydrogenase catalyzing the conversion of u03b2-1,3-glucanase activity into the corresponding aldonic acids, with a preference for u03b2-1,3-glucanase activity, with a preference for b3b2-1,3-glucanase, which is also shown by short u03b2-1,6 substitutions. We demonstrate that Um AA3_2-A's linear oligosaccharide products, released by Um GH161-1-A, are even more oxidized, revealing a putative biocatalytic cascade. We work on model u03b2-1,3-glucans. Interestingly, analysis of available transcriptomics results shows that both Um GH161-A and Um AA3_2-A are coexpressed, but only during the early stages of the U. maydis infection cycle. Regardless of their lifestyle, filamentous fungi must restore their own cell wall to expand and proliferate. However, scientific reports on fungal CAZymes over the past decade has mainly concentrated on plant biomass conversion techniques, though CAZymes directed at the fungus itself have remained little explored. We started to examine the prevalence of CAZymes directed toward the fungal cell wall during growth of the plant biomass in the present study, using the maize pathogen Ustilago maydis as a model, and characterized two new CAZymes focused on fungal cell wall components.

Source link: https://ui.adsabs.harvard.edu/abs/2022ApEnM..88E1581R/abstract


Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes

In a cross-sectional cohort of T1D patients and healthy controls, as well as in a longitudinal cohort, we examine the circulatory rates of ACAs against 202 glycans. We found 11 clusters of ACAs related to the glycan function class. ACAs against gentamicin and its related structures, G418 and sisomicin, are also linked to islet autoimmunity. ACAs can discriminate between T1D and non-existent participants of a population over a continuum with only clinical variables and are potential T1D biomarkers.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatCo..13.6527T/abstract


Design of amino acid- and carbohydrate-based anticancer drugs to inhibit polymerase η

U03b7 DNA polymerase u03b7 is of major importance in the development of new families of anticancer drugs. This protein plays a key role in several aspects of the cell cycle, including DNA replication, transletion DNA synthesis, and DNA repair. According to several studies, a high rate of polu03b7 expression in most cases has been correlated with low patient survival rates, regardless of the age of tumor cells. In recent years, the development of new drugs with fewer side effects to reduce polu03b7 in cancerous cells has attracted a lot of attention. These alternative inhibitors are supposed to disrupt the DNA replication process in cancerous cells and prevent tumor cells from mitosis. The inhibitors that contain amino acid and carbohydrate natural building blocks of amino acid and carbohydrate may be used as alternative drugs for Cytarabine to prevent polu03b7.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1218461K/abstract


Symbiotic microbes aid host adaptation by metabolizing a deterrent host pine carbohydrate d -pinitol in a beetle-fungus invasive complex

The red turpentine beetle is one of China's most destructive invasive rodents, and it solely consumes pine phloem containing high amounts of d -pinitol. Previous studies showed that d-pinitol has deterrent effects on insects. We found that d -pinitol had an antagonistic effect on RTB, which mostly relied on gallery microbes to degrade d -pinitol to improve host tolerance with mutualistic Leptographium procerum and two symbiotic bacteria, Erwinia and Serratia, which are responsible for this degradation. RTB helps RTB degrade a deterrent host pine carbohydrate D-pinitol in order to promote host adaptation.

Source link: https://ui.adsabs.harvard.edu/abs/2022SciA....8D5051L/abstract


Annona muricata L. peel extract inhibits carbohydrate metabolizing enzymes and reduces pancreatic β-cells, inflammation, and apoptosis via upregulation of PI3K/AKT genes

Annona muricata L. peel has been used for various ethnobotanical tasks, including diabetes control. The aim of this research was to determine the anti-diabetic activity of an aqueous extract of A. muricata peel and its effect on alloxan-induced diabetic rats. For twenty-one days, three groups were given doses of 6. 67, 13. 53, and 27. 06 mg/kg, along with a positive control group dose of 6. 67, 13. 53, and 27. 06 mg/kg. When compared to normal rats, AEAMP raised serum insulin levels, HOMA-u03b2, CAT, GST, and HDL-c. In addition, titramine, hexokinase, CAT, GST, and HDL-c. Liver PI3K, liver PCNA, and pancreas PCNA were not significantly different in diabetic rats, suggesting that alloxan induction of diabetes did not influence the expression of these genes in diabetic rats compared to normal rats, compared to diabetic rats, compared to diabetic rats, u03b2u002, CAT, t b-cell dysfunction by upregulating liver AKT and pancreatic PI3K and AKT genes, inhibiting carbohydrate metabolism enzymes, and preventing apoptosis by raising liver and pancreatic Bcl2.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1776984O/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions